OR4C6_HUMAN
ID OR4C6_HUMAN Reviewed; 309 AA.
AC Q8NH72; B2RP11; Q6IFD2;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Olfactory receptor 4C6;
DE AltName: Full=Olfactory receptor OR11-138;
GN Name=OR4C6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4C6";
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DR EMBL; AB065517; BAC05765.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW73679.1; -; Genomic_DNA.
DR EMBL; BC137216; AAI37217.1; -; mRNA.
DR EMBL; BC137218; AAI37219.1; -; mRNA.
DR EMBL; BK004330; DAA04728.1; -; Genomic_DNA.
DR CCDS; CCDS31506.1; -.
DR RefSeq; NP_001004704.1; NM_001004704.1.
DR AlphaFoldDB; Q8NH72; -.
DR SMR; Q8NH72; -.
DR STRING; 9606.ENSP00000324769; -.
DR GlyGen; Q8NH72; 1 site.
DR iPTMnet; Q8NH72; -.
DR PhosphoSitePlus; Q8NH72; -.
DR BioMuta; OR4C6; -.
DR DMDM; 38372822; -.
DR PaxDb; Q8NH72; -.
DR PeptideAtlas; Q8NH72; -.
DR PRIDE; Q8NH72; -.
DR Antibodypedia; 58938; 52 antibodies from 14 providers.
DR DNASU; 219432; -.
DR Ensembl; ENST00000314259.5; ENSP00000324769.3; ENSG00000181903.7.
DR Ensembl; ENST00000690330.1; ENSP00000508428.1; ENSG00000181903.7.
DR GeneID; 219432; -.
DR KEGG; hsa:219432; -.
DR MANE-Select; ENST00000314259.5; ENSP00000324769.3; NM_001004704.2; NP_001004704.1.
DR UCSC; uc010rik.2; human.
DR CTD; 219432; -.
DR GeneCards; OR4C6; -.
DR HGNC; HGNC:14743; OR4C6.
DR HPA; ENSG00000181903; Not detected.
DR neXtProt; NX_Q8NH72; -.
DR OpenTargets; ENSG00000181903; -.
DR PharmGKB; PA32264; -.
DR VEuPathDB; HostDB:ENSG00000181903; -.
DR eggNOG; ENOG502T8YI; Eukaryota.
DR GeneTree; ENSGT00940000158647; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NH72; -.
DR OMA; MKWEALV; -.
DR OrthoDB; 957049at2759; -.
DR PhylomeDB; Q8NH72; -.
DR TreeFam; TF352732; -.
DR PathwayCommons; Q8NH72; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219432; 56 hits in 670 CRISPR screens.
DR GeneWiki; OR4C6; -.
DR GenomeRNAi; 219432; -.
DR Pharos; Q8NH72; Tdark.
DR PRO; PR:Q8NH72; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH72; protein.
DR Bgee; ENSG00000181903; Expressed in tonsil and 2 other tissues.
DR ExpressionAtlas; Q8NH72; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 4C6"
FT /id="PRO_0000150531"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..287
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 133
FT /note="I -> T (in dbSNP:rs11230600)"
FT /id="VAR_034191"
SQ SEQUENCE 309 AA; 34558 MW; C481E2356F227426 CRC64;
MENQNNVTEF ILLGLTENLE LWKIFSAVFL VMYVATVLEN LLIVVTIITS QSLRSPMYFF
LTFLSLLDVM FSSVVAPKVI VDTLSKSTTI SLKGCLTQLF VEHFFGGVGI ILLTVMAYDR
YVAICKPLHY TIIMSPRVCC LMVGGAWVGG FMHAMIQLLF MYQIPFCGPN IIDHFICDLF
QLLTLACTDT HILGLLVTLN SGMMCVAIFL ILIASYTVIL CSLKSYSSKG RHKALSTCSS
HLTVVVLFFV PCIFLYMRPV VTHPIDKAMA VSDSIITPML NPLIYTLRNA EVKSAMKKLW
MKWEALAGK
