OR4CB_HUMAN
ID OR4CB_HUMAN Reviewed; 310 AA.
AC Q6IEV9; B9EIL4; Q8NGL8;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Olfactory receptor 4C11;
DE AltName: Full=Olfactory receptor OR11-136;
GN Name=OR4C11; Synonyms=OR4C11P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS THR-8 AND PRO-277.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-15.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4C11";
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DR EMBL; AB065774; BAC05994.1; -; Genomic_DNA.
DR EMBL; BC140727; AAI40728.1; -; mRNA.
DR EMBL; BK004503; DAA04901.1; -; Genomic_DNA.
DR CCDS; CCDS31503.1; -.
DR RefSeq; NP_001004700.2; NM_001004700.2.
DR AlphaFoldDB; Q6IEV9; -.
DR SMR; Q6IEV9; -.
DR STRING; 9606.ENSP00000306651; -.
DR GlyGen; Q6IEV9; 1 site.
DR iPTMnet; Q6IEV9; -.
DR PhosphoSitePlus; Q6IEV9; -.
DR BioMuta; OR4C11; -.
DR DMDM; 74762306; -.
DR PaxDb; Q6IEV9; -.
DR PeptideAtlas; Q6IEV9; -.
DR PRIDE; Q6IEV9; -.
DR Antibodypedia; 27133; 21 antibodies from 12 providers.
DR DNASU; 219429; -.
DR Ensembl; ENST00000641580.1; ENSP00000492971.1; ENSG00000172188.6.
DR GeneID; 219429; -.
DR KEGG; hsa:219429; -.
DR MANE-Select; ENST00000641580.1; ENSP00000492971.1; NM_001004700.3; NP_001004700.2.
DR UCSC; uc010rii.2; human.
DR CTD; 219429; -.
DR GeneCards; OR4C11; -.
DR HGNC; HGNC:15167; OR4C11.
DR HPA; ENSG00000172188; Not detected.
DR neXtProt; NX_Q6IEV9; -.
DR PharmGKB; PA32253; -.
DR VEuPathDB; HostDB:ENSG00000172188; -.
DR eggNOG; ENOG502SHD5; Eukaryota.
DR GeneTree; ENSGT00940000156137; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q6IEV9; -.
DR OMA; WHIKITA; -.
DR OrthoDB; 974882at2759; -.
DR PhylomeDB; Q6IEV9; -.
DR TreeFam; TF352732; -.
DR PathwayCommons; Q6IEV9; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219429; 11 hits in 673 CRISPR screens.
DR GeneWiki; OR4C11; -.
DR GenomeRNAi; 219429; -.
DR Pharos; Q6IEV9; Tdark.
DR PRO; PR:Q6IEV9; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6IEV9; protein.
DR ExpressionAtlas; Q6IEV9; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 4C11"
FT /id="PRO_0000150532"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..287
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 8
FT /note="P -> T (in dbSNP:rs491160)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_057543"
FT VARIANT 15
FT /note="L -> I (in dbSNP:rs11230346)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_057544"
FT VARIANT 277
FT /note="T -> P (in dbSNP:rs2456022)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_057545"
SQ SEQUENCE 310 AA; 35003 MW; 10435F9D98FAC123 CRC64;
MQQNNSVPEF ILLGLTQDPL RQKIVFVIFL IFYMGTVVGN MLIIVTIKSS RTLGSPMYFF
LFYLSFADSC FSTSTAPRLI VDALSEKKII TYNECMTQVF ALHLFGCMEI FVLILMAVDR
YVAICKPLRY PTIMSQQVCI ILIVLAWIGS LIHSTAQIIL ALRLPFCGPY LIDHYCCDLQ
PLLKLACMDT YMINLLLVSN SGAICSSSFM ILIISYIVIL HSLRNHSAKG KKKALSACTS
HIIVVILFFG PCIFIYTRPP TTFPMDKMVA VFYTIGTPFL NPLIYTLRNA EVKNAMRKLW
HGKIISENKG
