OR4CC_HUMAN
ID OR4CC_HUMAN Reviewed; 309 AA.
AC Q96R67; B2RNF0; Q6IF49;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Olfactory receptor 4C12;
DE AltName: Full=Olfactory receptor OR11-259;
GN Name=OR4C12;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-283.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-278.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4C12";
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DR EMBL; BC136850; AAI36851.1; -; mRNA.
DR EMBL; BC136851; AAI36852.1; -; mRNA.
DR EMBL; AF399576; AAK95061.1; -; Genomic_DNA.
DR EMBL; BK004413; DAA04811.1; -; Genomic_DNA.
DR CCDS; CCDS31496.1; -.
DR RefSeq; NP_001005270.3; NM_001005270.4.
DR AlphaFoldDB; Q96R67; -.
DR SMR; Q96R67; -.
DR STRING; 9606.ENSP00000334418; -.
DR GlyGen; Q96R67; 1 site.
DR iPTMnet; Q96R67; -.
DR PhosphoSitePlus; Q96R67; -.
DR BioMuta; OR4C12; -.
DR DMDM; 38372848; -.
DR PaxDb; Q96R67; -.
DR PeptideAtlas; Q96R67; -.
DR PRIDE; Q96R67; -.
DR TopDownProteomics; Q96R67; -.
DR Antibodypedia; 58926; 89 antibodies from 20 providers.
DR DNASU; 283093; -.
DR Ensembl; ENST00000335238.4; ENSP00000334418.4; ENSG00000221954.2.
DR Ensembl; ENST00000639310.1; ENSP00000491819.1; ENSG00000284255.1.
DR GeneID; 283093; -.
DR KEGG; hsa:283093; -.
DR MANE-Select; ENST00000335238.4; ENSP00000334418.4; NM_001005270.4; NP_001005270.3.
DR UCSC; uc010ria.2; human.
DR CTD; 283093; -.
DR GeneCards; OR4C12; -.
DR HGNC; HGNC:15168; OR4C12.
DR HPA; ENSG00000221954; Not detected.
DR neXtProt; NX_Q96R67; -.
DR OpenTargets; ENSG00000221954; -.
DR PharmGKB; PA32254; -.
DR VEuPathDB; HostDB:ENSG00000221954; -.
DR eggNOG; ENOG502SHUM; Eukaryota.
DR GeneTree; ENSGT00940000162374; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q96R67; -.
DR OMA; NGCMAQA; -.
DR OrthoDB; 897097at2759; -.
DR PhylomeDB; Q96R67; -.
DR TreeFam; TF337350; -.
DR PathwayCommons; Q96R67; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 283093; 8 hits in 623 CRISPR screens.
DR GeneWiki; OR4C12; -.
DR GenomeRNAi; 283093; -.
DR Pharos; Q96R67; Tdark.
DR PRO; PR:Q96R67; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q96R67; protein.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 4C12"
FT /id="PRO_0000150533"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..287
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 283
FT /note="V -> L (in dbSNP:rs4598671)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_034192"
SQ SEQUENCE 309 AA; 34491 MW; 3C6AD9FA309457C9 CRC64;
MEKKKNVTEF ILIGLTQNPI MEKVTFVVFL VLYMITLSGN LLIVVTITTS QALSSPMYFF
LTHLSLIDTV YSSSSAPKLI VDSFQEKKII SFNGCMAQAY AEHIFGATEI ILLTVMACDC
YVAICKPLNY TTIMSHSLCI LLVAVAWVGG FLHATIQILF TVWLPFCGPN VIGHFMCDLY
PLLKLVCIDT HTLGLFVAVN SGFICLLNFL ILVVSYVIIL RSLKNNSLEG RCKALSTCIS
HIIVVVLFFV PCIFVYLRSV TTLPIDKAVA VFYTMVVPML NPVVYTLRNA EVKSAIRKLW
RKKVTSDND
