OR4CD_HUMAN
ID OR4CD_HUMAN Reviewed; 309 AA.
AC Q8NGP0; A6NJJ3; B9EH30; Q6IF48; Q96R68;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Olfactory receptor 4C13;
DE AltName: Full=Olfactory receptor OR11-260;
GN Name=OR4C13;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ILE-133.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-133.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-278, AND VARIANT ILE-133.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [6]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [7]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4C13";
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DR EMBL; AB065750; BAC05970.1; -; Genomic_DNA.
DR EMBL; AP006587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC073113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471064; EAW67853.1; -; Genomic_DNA.
DR EMBL; BC137005; AAI37006.1; -; mRNA.
DR EMBL; AF399575; AAK95060.1; -; Genomic_DNA.
DR EMBL; BK004414; DAA04812.1; -; Genomic_DNA.
DR CCDS; CCDS31495.1; -.
DR RefSeq; NP_001001955.2; NM_001001955.2.
DR AlphaFoldDB; Q8NGP0; -.
DR SMR; Q8NGP0; -.
DR STRING; 9606.ENSP00000452277; -.
DR GlyGen; Q8NGP0; 2 sites.
DR iPTMnet; Q8NGP0; -.
DR PhosphoSitePlus; Q8NGP0; -.
DR BioMuta; OR4C13; -.
DR DMDM; 212276453; -.
DR PaxDb; Q8NGP0; -.
DR PeptideAtlas; Q8NGP0; -.
DR PRIDE; Q8NGP0; -.
DR Antibodypedia; 63202; 94 antibodies from 18 providers.
DR DNASU; 283092; -.
DR Ensembl; ENST00000555099.1; ENSP00000452277.1; ENSG00000258817.1.
DR GeneID; 283092; -.
DR KEGG; hsa:283092; -.
DR MANE-Select; ENST00000555099.1; ENSP00000452277.1; NM_001001955.2; NP_001001955.2.
DR UCSC; uc010rhz.2; human.
DR CTD; 283092; -.
DR DisGeNET; 283092; -.
DR GeneCards; OR4C13; -.
DR HGNC; HGNC:15169; OR4C13.
DR HPA; ENSG00000258817; Not detected.
DR neXtProt; NX_Q8NGP0; -.
DR PharmGKB; PA32255; -.
DR VEuPathDB; HostDB:ENSG00000258817; -.
DR eggNOG; ENOG502TE7F; Eukaryota.
DR GeneTree; ENSGT00940000154261; -.
DR HOGENOM; CLU_012526_0_1_1; -.
DR InParanoid; Q8NGP0; -.
DR OMA; HFFRGVE; -.
DR OrthoDB; 1023410at2759; -.
DR PhylomeDB; Q8NGP0; -.
DR TreeFam; TF352732; -.
DR PathwayCommons; Q8NGP0; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 283092; 12 hits in 623 CRISPR screens.
DR GeneWiki; OR4C13; -.
DR GenomeRNAi; 283092; -.
DR Pharos; Q8NGP0; Tdark.
DR PRO; PR:Q8NGP0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGP0; protein.
DR Bgee; ENSG00000258817; Expressed in prefrontal cortex.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 4C13"
FT /id="PRO_0000150534"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..287
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 87
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 2
FT /note="A -> V (in dbSNP:rs28378220)"
FT /id="VAR_067440"
FT VARIANT 133
FT /note="V -> I (in dbSNP:rs28662375)"
FT /evidence="ECO:0000269|PubMed:12213199,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_067441"
SQ SEQUENCE 309 AA; 34582 MW; 3EAD1271181FBFF2 CRC64;
MANRNNVTEF ILLGLTENPK MQKIIFVVFS VIYINAMIGN VLIVVTITAS PSLRSPMYFF
LAYLSFIDAC YSSVNTPKLI TDSLYENKTI LFNGCMTQVF GEHFFRGVEV ILLTVMAYDH
YVAICKPLHY TTVMKQHVCS LLVGVSWVGG FLHATIQILF ICQLPFCGPN VIDHFMCDLY
TLINLACTNT HTLGLFIAAN SGFICLLNCL LLLVSCVVIL YSLKTHSLEA RHEALSTCVS
HITVVILSFI PCIFVYMRPP ATLPIDKAVA VFYTMITSML NPLIYTLRNA QMKNAIRKLC
SRKAISSVK
