OR4CF_HUMAN
ID OR4CF_HUMAN Reviewed; 316 AA.
AC Q8NGM1; Q6IFE2;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Olfactory receptor 4C15;
DE AltName: Full=Olfactory receptor OR11-127;
DE AltName: Full=Olfactory receptor OR11-134;
GN Name=OR4C15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA04717.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=DAA04718.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4C15";
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DR EMBL; AB065771; BAC05991.1; -; Genomic_DNA.
DR EMBL; AP001998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004319; DAA04717.1; ALT_INIT; Genomic_DNA.
DR EMBL; BK004320; DAA04718.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS31501.1; -.
DR RefSeq; NP_001001920.1; NM_001001920.1.
DR AlphaFoldDB; Q8NGM1; -.
DR SMR; Q8NGM1; -.
DR BioGRID; 123440; 1.
DR STRING; 9606.ENSP00000324958; -.
DR GlyGen; Q8NGM1; 1 site.
DR iPTMnet; Q8NGM1; -.
DR PhosphoSitePlus; Q8NGM1; -.
DR BioMuta; OR4C15; -.
DR DMDM; 38372727; -.
DR PaxDb; Q8NGM1; -.
DR PeptideAtlas; Q8NGM1; -.
DR PRIDE; Q8NGM1; -.
DR Antibodypedia; 27128; 58 antibodies from 17 providers.
DR DNASU; 81309; -.
DR Ensembl; ENST00000642128.1; ENSP00000493126.1; ENSG00000181939.3.
DR GeneID; 81309; -.
DR KEGG; hsa:81309; -.
DR MANE-Select; ENST00000642128.1; ENSP00000493126.1; NM_001001920.3; NP_001001920.2.
DR UCSC; uc010rig.2; human.
DR CTD; 81309; -.
DR DisGeNET; 81309; -.
DR GeneCards; OR4C15; -.
DR HGNC; HGNC:15171; OR4C15.
DR HPA; ENSG00000181939; Not detected.
DR neXtProt; NX_Q8NGM1; -.
DR OpenTargets; ENSG00000181939; -.
DR VEuPathDB; HostDB:ENSG00000181939; -.
DR eggNOG; ENOG502SIY5; Eukaryota.
DR GeneTree; ENSGT00900000141017; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NGM1; -.
DR OMA; MGIAWMG; -.
DR OrthoDB; 971505at2759; -.
DR PhylomeDB; Q8NGM1; -.
DR TreeFam; TF352732; -.
DR PathwayCommons; Q8NGM1; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 81309; 4 hits in 663 CRISPR screens.
DR GeneWiki; OR4C15; -.
DR GenomeRNAi; 81309; -.
DR Pharos; Q8NGM1; Tdark.
DR PRO; PR:Q8NGM1; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGM1; protein.
DR ExpressionAtlas; Q8NGM1; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..316
FT /note="Olfactory receptor 4C15"
FT /id="PRO_0000150535"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..288
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 289..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 316 AA; 35667 MW; 9A77A664A489AAE1 CRC64;
MQNQSFVTEF VLLGLSQNPN VQEIVFVVFL FVYIATVGGN MLIVVTILSS PALLVSPMYF
FLGFLSFLDA CFSSVITPKM IVDSLYVTKT ISFEGCMMQL FAEHFFAGVE VIVLTAMAYD
RYVAICKPLH YSSIMNRRLC GILMGVAWTG GLLHSMIQIL FTFQLPFCGP NVINHFMCDL
YPLLELACTD THIFGLMVVI NSGFICIINF SLLLVSYAVI LLSLRTHSSE GRWKALSTCG
SHIAVVILFF VPCIFVYTRP PSAFSLDKMA AIFYIILNPL LNPLIYTFRN KEVKQAMRRI
WNRLMVVSDE KENIKL
