OR4CG_HUMAN
ID OR4CG_HUMAN Reviewed; 310 AA.
AC Q8NGL9; Q6IEV8;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Olfactory receptor 4C16;
DE AltName: Full=Olfactory receptor OR11-135;
GN Name=OR4C16;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-49; ALA-76 AND PRO-259.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4C16";
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DR EMBL; AB065773; BAC05993.1; -; Genomic_DNA.
DR EMBL; AP001998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004504; DAA04902.1; -; Genomic_DNA.
DR RefSeq; NP_001004701.2; NM_001004701.2.
DR AlphaFoldDB; Q8NGL9; -.
DR SMR; Q8NGL9; -.
DR STRING; 9606.ENSP00000324913; -.
DR GlyGen; Q8NGL9; 1 site.
DR iPTMnet; Q8NGL9; -.
DR PhosphoSitePlus; Q8NGL9; -.
DR BioMuta; OR4C16; -.
DR DMDM; 83305198; -.
DR PaxDb; Q8NGL9; -.
DR PeptideAtlas; Q8NGL9; -.
DR PRIDE; Q8NGL9; -.
DR ProteomicsDB; 73551; -.
DR Antibodypedia; 78655; 101 antibodies from 20 providers.
DR DNASU; 219428; -.
DR Ensembl; ENST00000623907.1; ENSP00000485295.1; ENSG00000279514.2.
DR GeneID; 219428; -.
DR KEGG; hsa:219428; -.
DR MANE-Select; ENST00000623907.1; ENSP00000485295.1; NM_001004701.2; NP_001004701.2.
DR UCSC; uc010rih.2; human.
DR CTD; 219428; -.
DR GeneCards; OR4C16; -.
DR HGNC; HGNC:15172; OR4C16.
DR HPA; ENSG00000279514; Not detected.
DR neXtProt; NX_Q8NGL9; -.
DR PharmGKB; PA32258; -.
DR VEuPathDB; HostDB:ENSG00000279514; -.
DR eggNOG; ENOG502SHD5; Eukaryota.
DR GeneTree; ENSGT00940000154976; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGL9; -.
DR OMA; NSRAICT; -.
DR OrthoDB; 905324at2759; -.
DR PhylomeDB; Q8NGL9; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NGL9; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219428; 13 hits in 664 CRISPR screens.
DR GeneWiki; OR4C16; -.
DR GenomeRNAi; 219428; -.
DR Pharos; Q8NGL9; Tdark.
DR PRO; PR:Q8NGL9; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGL9; protein.
DR Bgee; ENSG00000279514; Expressed in sural nerve.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 4C16"
FT /id="PRO_0000150536"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..287
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 25
FT /note="V -> L (in dbSNP:rs12800642)"
FT /id="VAR_053165"
FT VARIANT 49
FT /note="T -> A (in dbSNP:rs558465)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_053166"
FT VARIANT 76
FT /note="T -> A (in dbSNP:rs557590)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_034193"
FT VARIANT 203
FT /note="A -> T (in dbSNP:rs12288690)"
FT /id="VAR_053167"
FT VARIANT 259
FT /note="L -> P (in dbSNP:rs559449)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_053168"
SQ SEQUENCE 310 AA; 34991 MW; 87BA28E6BAB087AF CRC64;
MQLNNNVTEF ILLGLTQDPF WKKIVFVIFL RLYLGTLLGN LLIIISVKTS QALKNPMFFF
LFYLSLSDTC LSTSITPRMI VDALLKKTTI SFSECMIQVF SSHVFGCLEI FILILTAVDR
YVDICKPLHY MTIISQWVCG VLMAVAWVGS CVHSLVQIFL ALSLPFCGPN VINHCFCDLQ
PLLKQACSET YVVNLLLVSN SGAICAVSYV MLIFSYVIFL HSLRNHSAEV IKKALSTCVS
HIIVVILFFG PCIFMYTCLA TVFPMDKMIA VFYTVGTSFL NPVIYTLKNT EVKSAMRKLW
SKKLITDDKR
