OR4D1_HUMAN
ID OR4D1_HUMAN Reviewed; 310 AA.
AC Q15615; B2RN14; Q8NGB1; Q96R76;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 3.
DT 03-AUG-2022, entry version 172.
DE RecName: Full=Olfactory receptor 4D1;
DE AltName: Full=Olfactory receptor 4D3;
DE AltName: Full=Olfactory receptor TPCR16;
GN Name=OR4D1; Synonyms=OR4D3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-280, AND VARIANT ILE-174.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 126-279, AND VARIANT ILE-174.
RC TISSUE=Testis;
RX PubMed=9119360; DOI=10.1006/geno.1996.4490;
RA Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.;
RT "Specific repertoire of olfactory receptor genes in the male germ cells of
RT several mammalian species.";
RL Genomics 39:239-246(1997).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4D1";
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DR EMBL; AB065913; BAC06128.1; -; Genomic_DNA.
DR EMBL; AC005962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471109; EAW94482.1; -; Genomic_DNA.
DR EMBL; BC136589; AAI36590.1; -; mRNA.
DR EMBL; BC136595; AAI36596.1; -; mRNA.
DR EMBL; AF399567; AAK95052.1; -; Genomic_DNA.
DR EMBL; X89670; CAA61817.1; -; mRNA.
DR CCDS; CCDS42365.1; -.
DR PIR; S58015; S58015.
DR RefSeq; NP_036506.1; NM_012374.1.
DR AlphaFoldDB; Q15615; -.
DR SMR; Q15615; -.
DR BioGRID; 117790; 1.
DR STRING; 9606.ENSP00000365451; -.
DR GlyGen; Q15615; 1 site.
DR iPTMnet; Q15615; -.
DR PhosphoSitePlus; Q15615; -.
DR BioMuta; OR4D1; -.
DR DMDM; 290457670; -.
DR PaxDb; Q15615; -.
DR PeptideAtlas; Q15615; -.
DR PRIDE; Q15615; -.
DR Antibodypedia; 64084; 58 antibodies from 15 providers.
DR DNASU; 26689; -.
DR Ensembl; ENST00000268912.6; ENSP00000365451.3; ENSG00000141194.7.
DR Ensembl; ENST00000641449.1; ENSP00000493234.1; ENSG00000141194.7.
DR GeneID; 26689; -.
DR KEGG; hsa:26689; -.
DR MANE-Select; ENST00000268912.6; ENSP00000365451.3; NM_001386095.1; NP_001373024.1.
DR UCSC; uc010wno.3; human.
DR CTD; 26689; -.
DR DisGeNET; 26689; -.
DR GeneCards; OR4D1; -.
DR HGNC; HGNC:8293; OR4D1.
DR HPA; ENSG00000141194; Not detected.
DR neXtProt; NX_Q15615; -.
DR OpenTargets; ENSG00000141194; -.
DR PharmGKB; PA32267; -.
DR VEuPathDB; HostDB:ENSG00000141194; -.
DR eggNOG; ENOG502SIBY; Eukaryota.
DR GeneTree; ENSGT00940000154503; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q15615; -.
DR OMA; YSTVTCP; -.
DR OrthoDB; 987267at2759; -.
DR PhylomeDB; Q15615; -.
DR TreeFam; TF338273; -.
DR PathwayCommons; Q15615; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26689; 14 hits in 671 CRISPR screens.
DR GeneWiki; OR4D1; -.
DR GenomeRNAi; 26689; -.
DR Pharos; Q15615; Tdark.
DR PRO; PR:Q15615; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q15615; protein.
DR Bgee; ENSG00000141194; Expressed in granulocyte and 7 other tissues.
DR Genevisible; Q15615; HS.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 4D1"
FT /id="PRO_0000150537"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 54
FT /note="R -> Q (in dbSNP:rs12602205)"
FT /id="VAR_057546"
FT VARIANT 174
FT /note="L -> I (in dbSNP:rs7218964)"
FT /evidence="ECO:0000269|PubMed:12213199,
FT ECO:0000269|PubMed:9119360"
FT /id="VAR_060479"
FT CONFLICT 170
FT /note="G -> D (in Ref. 2; AAK95052 and 3; CAA61817)"
FT /evidence="ECO:0000305"
FT CONFLICT 201
FT /note="S -> F (in Ref. 2; AAK95052 and 3; CAA61817)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 310 AA; 35240 MW; 058A7B0E8A6CF672 CRC64;
MEPQNTTQVS MFVLLGFSQT QELQKFLFLL FLLVYVTTIV GNLLIMVTVT FDCRLHTPMY
FLLRNLALID LCYSTVTSPK MLVDFLHETK TISYQGCMAQ IFFFHLLGGG TVFFLSVMAY
DRYIAISQPL RYVTIMNTQL CVGLVVAAWV GGFVHSIVQL ALILPLPFCG PNILDNFYCD
VPQVLRLACT DTSLLEFLMI SNSGLLVIIW FLLLLISYTV ILVMLRSHSG KARRKAASTC
TTHIIVVSMI FIPCIYIYTW PFTPFLMDKA VSISYTVMTP MLNPMIYTLR NQDMKAAMRR
LGKCLVICRE
