OR4D2_HUMAN
ID OR4D2_HUMAN Reviewed; 307 AA.
AC P58180; Q6IFN8; Q96R75;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Olfactory receptor 4D2;
DE AltName: Full=B-lymphocyte membrane protein BC2009;
DE AltName: Full=Olfactory receptor OR17-24;
GN Name=OR4D2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Lu X.-W., Cui L.-X., Li Y.-H.;
RT "Activated B lymphocyte gene.";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-280.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4D2";
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DR EMBL; AF303373; AAL26785.1; -; mRNA.
DR EMBL; AB065912; BAC06127.1; -; Genomic_DNA.
DR EMBL; AC005962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF399568; AAK95053.1; -; Genomic_DNA.
DR EMBL; BK004224; DAA04622.1; -; Genomic_DNA.
DR CCDS; CCDS32688.1; -.
DR RefSeq; NP_001004707.1; NM_001004707.3.
DR AlphaFoldDB; P58180; -.
DR SMR; P58180; -.
DR BioGRID; 125872; 23.
DR STRING; 9606.ENSP00000441354; -.
DR GlyGen; P58180; 1 site.
DR iPTMnet; P58180; -.
DR PhosphoSitePlus; P58180; -.
DR BioMuta; OR4D2; -.
DR DMDM; 14423786; -.
DR jPOST; P58180; -.
DR PaxDb; P58180; -.
DR PeptideAtlas; P58180; -.
DR PRIDE; P58180; -.
DR Antibodypedia; 65981; 68 antibodies from 18 providers.
DR DNASU; 124538; -.
DR Ensembl; ENST00000545221.2; ENSP00000441354.1; ENSG00000255713.2.
DR Ensembl; ENST00000641866.1; ENSP00000493137.1; ENSG00000255713.2.
DR GeneID; 124538; -.
DR KEGG; hsa:124538; -.
DR MANE-Select; ENST00000545221.2; ENSP00000441354.1; NM_001004707.4; NP_001004707.1.
DR UCSC; uc010wnp.2; human.
DR CTD; 124538; -.
DR GeneCards; OR4D2; -.
DR HGNC; HGNC:8294; OR4D2.
DR HPA; ENSG00000255713; Not detected.
DR neXtProt; NX_P58180; -.
DR OpenTargets; ENSG00000255713; -.
DR PharmGKB; PA32270; -.
DR VEuPathDB; HostDB:ENSG00000255713; -.
DR eggNOG; ENOG502SIBY; Eukaryota.
DR GeneTree; ENSGT00940000154503; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; P58180; -.
DR OMA; IYQLALM; -.
DR OrthoDB; 987267at2759; -.
DR PhylomeDB; P58180; -.
DR TreeFam; TF338273; -.
DR PathwayCommons; P58180; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 124538; 7 hits in 667 CRISPR screens.
DR GeneWiki; OR4D2; -.
DR GenomeRNAi; 124538; -.
DR Pharos; P58180; Tdark.
DR PRO; PR:P58180; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; P58180; protein.
DR ExpressionAtlas; P58180; baseline and differential.
DR Genevisible; P58180; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..307
FT /note="Olfactory receptor 4D2"
FT /id="PRO_0000150538"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..307
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 29
FT /note="L -> I (in dbSNP:rs60994383)"
FT /id="VAR_062035"
SQ SEQUENCE 307 AA; 34958 MW; 5C8C68269034EBD3 CRC64;
METGNLTWVS DFVFLGLSQT RELQRFLFLM FLFVYITTVM GNILIIITVT SDSQLHTPMY
FLLRNLAVLD LCFSSVTAPK MLVDLLSEKK TISYQGCMGQ IFFFHFLGGA MVFFLSVMAF
DRLIAISRPL RYVTVMNTQL WVGLVVATWV GGFVHSIVQL ALMLPLPFCG PNILDNFYCD
VPQVLRLACT DTSLLEFLKI SNSGLLDVVW FFLLLMSYLF ILVMLRSHPG EARRKAASTC
TTHIIVVSMI FVPSIYLYAR PFTPFPMDKL VSIGHTVMTP MLNPMIYTLR NQDMQAAVRR
LGRHRLV
