OR4D5_HUMAN
ID OR4D5_HUMAN Reviewed; 318 AA.
AC Q8NGN0; B9EGZ4; Q6IFE6;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Olfactory receptor 4D5;
DE AltName: Full=Olfactory receptor OR11-276;
GN Name=OR4D5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4D5";
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DR EMBL; AB065760; BAC05980.1; -; Genomic_DNA.
DR EMBL; CH471065; EAW67561.1; -; Genomic_DNA.
DR EMBL; BC136943; AAI36944.1; -; mRNA.
DR EMBL; BC136945; AAI36946.1; -; mRNA.
DR EMBL; BK004316; DAA04714.1; -; Genomic_DNA.
DR CCDS; CCDS31699.1; -.
DR RefSeq; NP_001001965.1; NM_001001965.1.
DR AlphaFoldDB; Q8NGN0; -.
DR SMR; Q8NGN0; -.
DR STRING; 9606.ENSP00000305970; -.
DR GlyGen; Q8NGN0; 1 site.
DR iPTMnet; Q8NGN0; -.
DR PhosphoSitePlus; Q8NGN0; -.
DR BioMuta; OR4D5; -.
DR DMDM; 38372730; -.
DR PaxDb; Q8NGN0; -.
DR PRIDE; Q8NGN0; -.
DR Antibodypedia; 49667; 20 antibodies from 12 providers.
DR DNASU; 219875; -.
DR Ensembl; ENST00000307033.3; ENSP00000305970.2; ENSG00000171014.3.
DR GeneID; 219875; -.
DR KEGG; hsa:219875; -.
DR MANE-Select; ENST00000307033.3; ENSP00000305970.2; NM_001001965.1; NP_001001965.1.
DR UCSC; uc001pzk.2; human.
DR CTD; 219875; -.
DR GeneCards; OR4D5; -.
DR HGNC; HGNC:14852; OR4D5.
DR HPA; ENSG00000171014; Not detected.
DR neXtProt; NX_Q8NGN0; -.
DR OpenTargets; ENSG00000171014; -.
DR PharmGKB; PA32272; -.
DR VEuPathDB; HostDB:ENSG00000171014; -.
DR eggNOG; ENOG502SIBY; Eukaryota.
DR GeneTree; ENSGT00940000163057; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGN0; -.
DR OMA; YFMTVVG; -.
DR OrthoDB; 987267at2759; -.
DR PhylomeDB; Q8NGN0; -.
DR TreeFam; TF352732; -.
DR PathwayCommons; Q8NGN0; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219875; 8 hits in 669 CRISPR screens.
DR GeneWiki; OR4D5; -.
DR GenomeRNAi; 219875; -.
DR Pharos; Q8NGN0; Tdark.
DR PRO; PR:Q8NGN0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGN0; protein.
DR Bgee; ENSG00000171014; Expressed in body of pancreas and 1 other tissue.
DR ExpressionAtlas; Q8NGN0; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..318
FT /note="Olfactory receptor 4D5"
FT /id="PRO_0000150539"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..318
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 318 AA; 35771 MW; 587D3AF60FF8B135 CRC64;
MNPANHSQVA GFVLLGLSQV WELRFVFFTV FSAVYFMTVV GNLLIVVIVT SDPHLHTTMY
FLLGNLSFLD FCYSSITAPR MLVDLLSGNP TISFGGCLTQ LFFFHFIGGI KIFLLTVMAY
DRYIAISQPL HYTLIMNQTV CALLMAASWV GGFIHSIVQI ALTIQLPFCG PDKLDNFYCD
VPQLIKLACT DTFVLELLMV SNNGLVTLMC FLVLLGSYTA LLVMLRSHSR EGRSKALSTC
ASHIAVVTLI FVPCIYVYTR PFRTFPMDKA VSVLYTIVTP MLNPAIYTLR NKEVIMAMKK
LWRRKKDPIG PLEHRPLH
