OR4D6_HUMAN
ID OR4D6_HUMAN Reviewed; 314 AA.
AC Q8NGJ1; B2RNP7; Q6IFF5; Q96R74;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Olfactory receptor 4D6;
DE AltName: Full=Olfactory receptor OR11-250;
GN Name=OR4D6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLY-96.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-96.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-280.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4D6";
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DR EMBL; AB065803; BAC06022.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW73845.1; -; Genomic_DNA.
DR EMBL; BC137028; AAI37029.1; -; mRNA.
DR EMBL; BC137029; AAI37030.1; -; mRNA.
DR EMBL; AF399569; AAK95054.1; -; Genomic_DNA.
DR EMBL; BK004307; DAA04705.1; -; Genomic_DNA.
DR CCDS; CCDS31562.1; -.
DR RefSeq; NP_001004708.1; NM_001004708.1.
DR AlphaFoldDB; Q8NGJ1; -.
DR SMR; Q8NGJ1; -.
DR BioGRID; 128611; 16.
DR IntAct; Q8NGJ1; 1.
DR MINT; Q8NGJ1; -.
DR STRING; 9606.ENSP00000300127; -.
DR GlyGen; Q8NGJ1; 2 sites, 1 O-linked glycan (1 site).
DR PhosphoSitePlus; Q8NGJ1; -.
DR BioMuta; OR4D6; -.
DR DMDM; 38372703; -.
DR MassIVE; Q8NGJ1; -.
DR PaxDb; Q8NGJ1; -.
DR PeptideAtlas; Q8NGJ1; -.
DR PRIDE; Q8NGJ1; -.
DR ProteomicsDB; 73527; -.
DR Antibodypedia; 27754; 100 antibodies from 20 providers.
DR DNASU; 219983; -.
DR Ensembl; ENST00000300127.3; ENSP00000300127.2; ENSG00000166884.3.
DR GeneID; 219983; -.
DR KEGG; hsa:219983; -.
DR MANE-Select; ENST00000300127.3; ENSP00000300127.2; NM_001004708.1; NP_001004708.1.
DR UCSC; uc010rku.3; human.
DR CTD; 219983; -.
DR DisGeNET; 219983; -.
DR GeneCards; OR4D6; -.
DR HGNC; HGNC:15175; OR4D6.
DR HPA; ENSG00000166884; Not detected.
DR neXtProt; NX_Q8NGJ1; -.
DR OpenTargets; ENSG00000166884; -.
DR PharmGKB; PA32273; -.
DR VEuPathDB; HostDB:ENSG00000166884; -.
DR eggNOG; ENOG502RCKG; Eukaryota.
DR GeneTree; ENSGT00940000163118; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGJ1; -.
DR OMA; TITCESH; -.
DR OrthoDB; 987267at2759; -.
DR PhylomeDB; Q8NGJ1; -.
DR TreeFam; TF352732; -.
DR PathwayCommons; Q8NGJ1; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGJ1; -.
DR BioGRID-ORCS; 219983; 7 hits in 671 CRISPR screens.
DR GeneWiki; OR4D6; -.
DR GenomeRNAi; 219983; -.
DR Pharos; Q8NGJ1; Tdark.
DR PRO; PR:Q8NGJ1; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGJ1; protein.
DR Bgee; ENSG00000166884; Expressed in vermiform appendix and 4 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 4D6"
FT /id="PRO_0000150540"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 11
FT /note="E -> Q (in dbSNP:rs17153766)"
FT /id="VAR_034194"
FT VARIANT 59
FT /note="M -> V (in dbSNP:rs1453544)"
FT /id="VAR_053169"
FT VARIANT 96
FT /note="D -> G (in dbSNP:rs1453543)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_024091"
FT VARIANT 102
FT /note="F -> S (in dbSNP:rs17153770)"
FT /id="VAR_034195"
FT VARIANT 111
FT /note="D -> A (in dbSNP:rs17500380)"
FT /id="VAR_034196"
FT VARIANT 151
FT /note="S -> T (in dbSNP:rs1453542)"
FT /id="VAR_024092"
FT VARIANT 263
FT /note="M -> T (in dbSNP:rs1453541)"
FT /id="VAR_024093"
SQ SEQUENCE 314 AA; 35954 MW; FA70D423F278502E CRC64;
MDQINHTNVK EFFFLELTRS RELEFFLFVV FFAVYVATVL GNALIVVTIT CESRLHTPMY
FLLRNKSVLD IVFSSITVPK FLVDLLSDRK TISYNDCMAQ IFFFHFAGGA DIFFLSVMAY
DRYLAIAKPL HYVTMMRKEV WVALVVASWV SGGLHSIIQV ILMLPFPFCG PNTLDAFYCY
VLQVVKLACT DTFALELFMI SNNGLVTLLW FLLLLGSYTV ILVMLRSHSG EGRNKALSTC
TSHMLVVTLH FVPCVYIYCR PFMTLPMDTT ISINNTVITP MLNPIIYSLR NQEMKSAMQR
LQRRLGPSES RKWG
