OR4D9_HUMAN
ID OR4D9_HUMAN Reviewed; 314 AA.
AC Q8NGE8; Q6IFF3;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 3.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Olfactory receptor 4D9;
DE AltName: Full=Olfactory receptor OR11-253;
GN Name=OR4D9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4D9";
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DR EMBL; AB065861; BAC06079.1; -; Genomic_DNA.
DR EMBL; AC019093; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004309; DAA04707.1; -; Genomic_DNA.
DR CCDS; CCDS31564.1; -.
DR RefSeq; NP_001004711.1; NM_001004711.1.
DR AlphaFoldDB; Q8NGE8; -.
DR SMR; Q8NGE8; -.
DR STRING; 9606.ENSP00000328563; -.
DR GlyGen; Q8NGE8; 1 site.
DR PhosphoSitePlus; Q8NGE8; -.
DR BioMuta; OR4D9; -.
DR DMDM; 134047863; -.
DR PaxDb; Q8NGE8; -.
DR PeptideAtlas; Q8NGE8; -.
DR PRIDE; Q8NGE8; -.
DR Antibodypedia; 78031; 11 antibodies from 8 providers.
DR DNASU; 390199; -.
DR Ensembl; ENST00000641278.1; ENSP00000493042.1; ENSG00000172742.6.
DR Ensembl; ENST00000641962.1; ENSP00000493010.1; ENSG00000172742.6.
DR GeneID; 390199; -.
DR KEGG; hsa:390199; -.
DR MANE-Select; ENST00000641962.1; ENSP00000493010.1; NM_001004711.2; NP_001004711.1.
DR UCSC; uc010rkv.2; human.
DR CTD; 390199; -.
DR GeneCards; OR4D9; -.
DR HGNC; HGNC:15178; OR4D9.
DR HPA; ENSG00000172742; Tissue enhanced (brain).
DR neXtProt; NX_Q8NGE8; -.
DR OpenTargets; ENSG00000172742; -.
DR PharmGKB; PA32276; -.
DR VEuPathDB; HostDB:ENSG00000172742; -.
DR eggNOG; ENOG502SIBY; Eukaryota.
DR GeneTree; ENSGT00940000164403; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGE8; -.
DR OMA; MTIMSKG; -.
DR OrthoDB; 1075795at2759; -.
DR PhylomeDB; Q8NGE8; -.
DR TreeFam; TF352732; -.
DR PathwayCommons; Q8NGE8; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390199; 29 hits in 668 CRISPR screens.
DR GeneWiki; OR4D9; -.
DR GenomeRNAi; 390199; -.
DR Pharos; Q8NGE8; Tdark.
DR PRO; PR:Q8NGE8; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGE8; protein.
DR ExpressionAtlas; Q8NGE8; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 4D9"
FT /id="PRO_0000150541"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 159
FT /note="Q -> R (in dbSNP:rs17501584)"
FT /id="VAR_053170"
FT CONFLICT 147..153
FT /note="ASWVGGF -> GFLGGGL (in Ref. 2; AC019093)"
FT /evidence="ECO:0000305"
FT CONFLICT 168
FT /note="F -> V (in Ref. 2; AC019093)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 314 AA; 35666 MW; 87C891A59D57CFC2 CRC64;
MDQRNYTRVK EFTFLGITQS RELSQVLFTF LFLVYMTTLM GNFLIMVTVT CESHLHTPMY
FLLRNLSILD ICFSSITAPK VLIDLLSETK TISFSGCVTQ MFFFHLLGGA DVFSLSVMAF
DRYIAISKPL HYMTIMSRGR CTGLIVASWV GGFVHSIAQI SLLLPLPFCG PNVLDTFYCD
VPQVLKLACT DTFTLELLMI SNNGLVSWFV FFFLLISYTV ILMMLRSHTG EGRRKAISTC
TSHITVVTLH FVPCIYVYAR PFTALPTDTA ISVTFTVISP LLNPIIYTLR NQEMKLAMRK
LKRRLGQSER ILIQ
