OR4DA_HUMAN
ID OR4DA_HUMAN Reviewed; 311 AA.
AC Q8NGI6; B2RNH6;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Olfactory receptor 4D10;
DE AltName: Full=Olfactory receptor OR11-251;
GN Name=OR4D10; Synonyms=OR4D10P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4D10";
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DR EMBL; AB065808; BAC06027.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW73846.1; -; Genomic_DNA.
DR EMBL; BC136893; AAI36894.1; -; mRNA.
DR EMBL; BC136894; AAI36895.1; -; mRNA.
DR EMBL; BK004311; DAA04709.1; -; Genomic_DNA.
DR CCDS; CCDS53636.1; -.
DR RefSeq; NP_001004705.1; NM_001004705.1.
DR AlphaFoldDB; Q8NGI6; -.
DR SMR; Q8NGI6; -.
DR BioGRID; 133440; 3.
DR STRING; 9606.ENSP00000436424; -.
DR GlyGen; Q8NGI6; 1 site.
DR iPTMnet; Q8NGI6; -.
DR PhosphoSitePlus; Q8NGI6; -.
DR BioMuta; OR4D10; -.
DR DMDM; 71153029; -.
DR PaxDb; Q8NGI6; -.
DR PeptideAtlas; Q8NGI6; -.
DR PRIDE; Q8NGI6; -.
DR Antibodypedia; 70738; 19 antibodies from 11 providers.
DR DNASU; 390197; -.
DR Ensembl; ENST00000530162.2; ENSP00000436424.1; ENSG00000254466.2.
DR GeneID; 390197; -.
DR KEGG; hsa:390197; -.
DR MANE-Select; ENST00000530162.2; ENSP00000436424.1; NM_001004705.2; NP_001004705.1.
DR UCSC; uc001nnz.2; human.
DR CTD; 390197; -.
DR GeneCards; OR4D10; -.
DR HGNC; HGNC:15173; OR4D10.
DR HPA; ENSG00000254466; Not detected.
DR neXtProt; NX_Q8NGI6; -.
DR OpenTargets; ENSG00000254466; -.
DR PharmGKB; PA32268; -.
DR VEuPathDB; HostDB:ENSG00000254466; -.
DR eggNOG; ENOG502SIBY; Eukaryota.
DR GeneTree; ENSGT00940000157204; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGI6; -.
DR OMA; MENCTRV; -.
DR OrthoDB; 1075795at2759; -.
DR PhylomeDB; Q8NGI6; -.
DR TreeFam; TF352732; -.
DR PathwayCommons; Q8NGI6; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390197; 10 hits in 654 CRISPR screens.
DR GeneWiki; OR4D10; -.
DR GenomeRNAi; 390197; -.
DR Pharos; Q8NGI6; Tdark.
DR PRO; PR:Q8NGI6; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGI6; protein.
DR Bgee; ENSG00000254466; Expressed in cortical plate.
DR ExpressionAtlas; Q8NGI6; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 4D10"
FT /id="PRO_0000150542"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 311 AA; 35300 MW; E690167222E55D72 CRC64;
MEMENCTRVK EFIFLGLTQN REVSLVLFLF LLLVYVTTLL GNLLIMVTVT CESRLHTPMY
FLLHNLSIAD ICFSSITVPK VLVDLLSERK TISFNHCFTQ MFLFHLIGGV DVFSLSVMAL
DRYVAISKPL HYATIMSRDH CIGLTVAAWL GGFVHSIVQI SLLLPLPFCG PNVLDTFYCD
VHRVLKLAHT DIFILELLMI SNNGLLTTLW FFLLLVSYIV ILSLPKSQAG EGRRKAISTC
TSHITVVTLH FVPCIYVYAR PFTALPMDKA ISVTFTVISP LLNPLIYTLR NHEMKSAMRR
LKRRLVPSDR K
