OR4DB_HUMAN
ID OR4DB_HUMAN Reviewed; 311 AA.
AC Q8NGI4;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Olfactory receptor 4D11;
GN Name=OR4D11; Synonyms=OR4D11P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4D11";
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DR EMBL; AB065810; BAC06029.1; -; Genomic_DNA.
DR CCDS; CCDS31563.1; -.
DR RefSeq; NP_001004706.1; NM_001004706.1.
DR AlphaFoldDB; Q8NGI4; -.
DR SMR; Q8NGI4; -.
DR STRING; 9606.ENSP00000320077; -.
DR GlyGen; Q8NGI4; 1 site.
DR PhosphoSitePlus; Q8NGI4; -.
DR BioMuta; OR4D11; -.
DR DMDM; 71153030; -.
DR PaxDb; Q8NGI4; -.
DR PeptideAtlas; Q8NGI4; -.
DR PRIDE; Q8NGI4; -.
DR Antibodypedia; 65199; 64 antibodies from 19 providers.
DR DNASU; 219986; -.
DR Ensembl; ENST00000313253.1; ENSP00000320077.1; ENSG00000176200.1.
DR GeneID; 219986; -.
DR KEGG; hsa:219986; -.
DR MANE-Select; ENST00000313253.1; ENSP00000320077.1; NM_001004706.1; NP_001004706.1.
DR UCSC; uc001noa.1; human.
DR CTD; 219986; -.
DR GeneCards; OR4D11; -.
DR HGNC; HGNC:15174; OR4D11.
DR HPA; ENSG00000176200; Not detected.
DR neXtProt; NX_Q8NGI4; -.
DR OpenTargets; ENSG00000176200; -.
DR PharmGKB; PA32269; -.
DR VEuPathDB; HostDB:ENSG00000176200; -.
DR eggNOG; ENOG502SIBY; Eukaryota.
DR GeneTree; ENSGT00940000163523; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGI4; -.
DR OMA; CFVYMTT; -.
DR OrthoDB; 1075795at2759; -.
DR PhylomeDB; Q8NGI4; -.
DR TreeFam; TF352732; -.
DR PathwayCommons; Q8NGI4; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGI4; -.
DR BioGRID-ORCS; 219986; 15 hits in 670 CRISPR screens.
DR GeneWiki; OR4D11; -.
DR GenomeRNAi; 219986; -.
DR Pharos; Q8NGI4; Tdark.
DR PRO; PR:Q8NGI4; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGI4; protein.
DR ExpressionAtlas; Q8NGI4; differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 4D11"
FT /id="PRO_0000150543"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 197
FT /note="F -> L (in dbSNP:rs7120079)"
FT /id="VAR_034197"
SQ SEQUENCE 311 AA; 34969 MW; 503FDDBFCACABC61 CRC64;
MELGNVTRVK EFIFLGLTQS QDQSLVLFLF LCLVYMTTLL GNLLIMVTVT CESRLHTPMY
FLLRNLAILD ICFSSTTAPK VLLDLLSKKK TISYTSCMTQ IFLFHLLGGA DIFSLSVMAF
DCYMAISKPL HYVTIMSRGQ CTALISASWM GGFVHSIVQI SLLLPLPFCG PNVLDTFYCD
VPQVLKLTCT DTFALEFLMI SNNGLVTTLW FIFLLVSYTV ILMTLRSQAG GGRRKAISTC
TSHITVVTLH FVPCIYVYAR PFTALPTEKA ISVTFTVISP LLNPLIYTLR NQEMKSAMRR
LKRRLVPSER E
