OR4E2_HUMAN
ID OR4E2_HUMAN Reviewed; 313 AA.
AC Q8NGC2; Q6IET6; Q96R62;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Olfactory receptor 4E2;
DE AltName: Full=Olfactory receptor OR14-42;
GN Name=OR4E2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-280.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4E2";
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DR EMBL; AB065895; BAC06111.1; -; Genomic_DNA.
DR EMBL; AF399581; AAK95066.1; -; Genomic_DNA.
DR EMBL; BK004526; DAA04924.1; -; Genomic_DNA.
DR CCDS; CCDS41916.1; -.
DR AlphaFoldDB; Q8NGC2; -.
DR SMR; Q8NGC2; -.
DR STRING; 9606.ENSP00000386195; -.
DR GlyGen; Q8NGC2; 1 site.
DR iPTMnet; Q8NGC2; -.
DR PhosphoSitePlus; Q8NGC2; -.
DR BioMuta; OR4E2; -.
DR DMDM; 38372663; -.
DR MassIVE; Q8NGC2; -.
DR PaxDb; Q8NGC2; -.
DR PRIDE; Q8NGC2; -.
DR Antibodypedia; 58801; 40 antibodies from 14 providers.
DR DNASU; 26686; -.
DR UCSC; uc010tmd.2; human.
DR GeneCards; OR4E2; -.
DR HGNC; HGNC:8297; OR4E2.
DR HPA; ENSG00000221977; Not detected.
DR neXtProt; NX_Q8NGC2; -.
DR PharmGKB; PA32278; -.
DR VEuPathDB; HostDB:ENSG00000221977; -.
DR eggNOG; ENOG502RCGN; Eukaryota.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGC2; -.
DR PhylomeDB; Q8NGC2; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NGC2; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR Pharos; Q8NGC2; Tdark.
DR PRO; PR:Q8NGC2; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NGC2; protein.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 4E2"
FT /id="PRO_0000150544"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 118
FT /note="V -> M (in dbSNP:rs2874103)"
FT /id="VAR_034198"
FT VARIANT 234
FT /note="Q -> R (in dbSNP:rs970382)"
FT /id="VAR_034199"
SQ SEQUENCE 313 AA; 35466 MW; 59A922BBA6978452 CRC64;
MDSLNQTRVT EFVFLGLTDN RVLEMLFFMA FSAIYMLTLS GNILIIIATV FTPSLHTPMY
FFLSNLSFID ICHSSVTVPK MLEGLLLERK TISFDNCITQ LFFLHLFACA EIFLLIIVAY
DRYVAICTPL HYPNVMNMRV CIQLVFALWL GGTVHSLGQT FLTIRLPYCG PNIIDSYFCD
VPLVIKLACT DTYLTGILIV TNSGTISLSC FLAVVTSYMV ILVSLRKHSA EGRQKALSTC
SAHFMVVALF FGPCIFIYTR PDTSFSIDKV VSVFYTVVTP LLNPFIYTLR NEEVKSAMKQ
LRQRQVFFTK SYT
