OR4F3_HUMAN
ID OR4F3_HUMAN Reviewed; 312 AA.
AC Q6IEY1; B2RPQ6;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Olfactory receptor 4F3/4F16/4F29;
DE AltName: Full=Olfactory receptor OR1-1;
GN Name=OR4F3;
GN and
GN Name=OR4F16;
GN and
GN Name=OR4F29;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- INTERACTION:
CC Q6IEY1; P0CB47: UBTFL1; NbExp=3; IntAct=EBI-18294332, EBI-17208936;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4F29";
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4F3";
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4F16";
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DR EMBL; AL732372; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137547; AAI37548.1; -; mRNA.
DR EMBL; BK004481; DAA04879.1; -; Genomic_DNA.
DR CCDS; CCDS41221.1; -.
DR CCDS; CCDS43415.1; -.
DR CCDS; CCDS72675.1; -.
DR RefSeq; NP_001005221.2; NM_001005221.2.
DR RefSeq; NP_001005224.1; NM_001005224.1.
DR RefSeq; NP_001005277.1; NM_001005277.1.
DR RefSeq; XP_016857897.1; XM_017002408.1.
DR RefSeq; XP_016857898.1; XM_017002409.1.
DR RefSeq; XP_016857899.1; XM_017002410.1.
DR RefSeq; XP_016857900.1; XM_017002411.1.
DR RefSeq; XP_016864827.1; XM_017009338.1.
DR AlphaFoldDB; Q6IEY1; -.
DR SMR; Q6IEY1; -.
DR BioGRID; 117786; 1.
DR BioGRID; 123472; 1.
DR BioGRID; 610156; 1.
DR IntAct; Q6IEY1; 1.
DR STRING; 9606.ENSP00000329982; -.
DR GlyGen; Q6IEY1; 1 site.
DR iPTMnet; Q6IEY1; -.
DR PhosphoSitePlus; Q6IEY1; -.
DR BioMuta; OR4F16; -.
DR DMDM; 74762307; -.
DR PaxDb; Q6IEY1; -.
DR PRIDE; Q6IEY1; -.
DR Antibodypedia; 57198; 61 antibodies from 14 providers.
DR Antibodypedia; 78854; 1 antibodies from 1 providers.
DR Antibodypedia; 78873; 11 antibodies from 3 providers.
DR DNASU; 729759; -.
DR Ensembl; ENST00000332831.5; ENSP00000329982.2; ENSG00000284662.2.
DR Ensembl; ENST00000426406.4; ENSP00000409316.1; ENSG00000284733.2.
DR Ensembl; ENST00000456475.1; ENSP00000394282.1; ENSG00000230178.1.
DR GeneID; 26683; -.
DR GeneID; 729759; -.
DR GeneID; 81399; -.
DR KEGG; hsa:26683; -.
DR KEGG; hsa:729759; -.
DR KEGG; hsa:81399; -.
DR MANE-Select; ENST00000332831.5; ENSP00000329982.2; NM_001005277.1; NP_001005277.1.
DR MANE-Select; ENST00000426406.4; ENSP00000409316.1; NM_001005221.2; NP_001005221.2.
DR UCSC; uc010nxu.2; human.
DR CTD; 26683; -.
DR CTD; 729759; -.
DR CTD; 81399; -.
DR GeneCards; OR4F16; -.
DR GeneCards; OR4F29; -.
DR GeneCards; OR4F3; -.
DR HGNC; HGNC:15079; OR4F16.
DR HGNC; HGNC:31275; OR4F29.
DR HGNC; HGNC:8300; OR4F3.
DR HPA; ENSG00000230178; Not detected.
DR HPA; ENSG00000284662; Not detected.
DR HPA; ENSG00000284733; Not detected.
DR neXtProt; NX_Q6IEY1; -.
DR PharmGKB; PA32284; -.
DR VEuPathDB; HostDB:ENSG00000230178; -.
DR VEuPathDB; HostDB:ENSG00000284662; -.
DR VEuPathDB; HostDB:ENSG00000284733; -.
DR eggNOG; ENOG502TEJE; Eukaryota.
DR GeneTree; ENSGT00940000162683; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q6IEY1; -.
DR OMA; PLMIFRK; -.
DR OrthoDB; 947815at2759; -.
DR PhylomeDB; Q6IEY1; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; Q6IEY1; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26683; 11 hits in 136 CRISPR screens.
DR BioGRID-ORCS; 729759; 8 hits in 135 CRISPR screens.
DR BioGRID-ORCS; 81399; 57 hits in 553 CRISPR screens.
DR GeneWiki; OR4F16; -.
DR GeneWiki; OR4F3; -.
DR Pharos; Q6IEY1; Tdark.
DR PRO; PR:Q6IEY1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q6IEY1; protein.
DR Bgee; ENSG00000230178; Expressed in right lobe of liver and 21 other tissues.
DR ExpressionAtlas; Q6IEY1; baseline.
DR Genevisible; Q6IEY1; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 4F3/4F16/4F29"
FT /id="PRO_0000150551"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 312 AA; 35074 MW; 08285B196DC638FB CRC64;
MDGENHSVVS EFLFLGLTHS WEIQLLLLVF SSVLYVASIT GNILIVFSVT TDPHLHSPMY
FLLASLSFID LGACSVTSPK MIYDLFRKRK VISFGGCIAQ IFFIHVVGGV EMVLLIAMAF
DRYVALCKPL HYLTIMSPRM CLSFLAVAWT LGVSHSLFQL AFLVNLAFCG PNVLDSFYCD
LPRLLRLACT DTYRLQFMVT VNSGFICVGT FFILLISYVF ILFTVWKHSS GGSSKALSTL
SAHSTVVLLF FGPPMFVYTR PHPNSQMDKF LAIFDAVLTP FLNPVVYTFR NKEMKAAIKR
VCKQLVIYKR IS
