OR4F4_HUMAN
ID OR4F4_HUMAN Reviewed; 305 AA.
AC Q96R69; B2RNI5; Q6IFN9;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Olfactory receptor 4F4;
DE AltName: Full=HS14a-1-A;
DE AltName: Full=Olfactory receptor OR19-3;
GN Name=OR4F4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9384599; DOI=10.1093/hmg/7.1.13;
RA Trask B.J., Friedman C., Martin-Gallardo A., Rowen L., Akinbami C.,
RA Blankenship J., Collins C., Giorgi D., Iadonato S., Johnson F., Kuo W.L.,
RA Massa H., Morrish T., Naylor S., Nguyen O.T., Rouquier S., Smith T.,
RA Wong D.J., Youngblom J., van den Engh G.;
RT "Members of the olfactory receptor gene family are contained in large
RT blocks of DNA duplicated polymorphically near the ends of human
RT chromosomes.";
RL Hum. Mol. Genet. 7:13-26(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 61-274.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4F4";
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DR EMBL; L78442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136907; AAI36908.1; -; mRNA.
DR EMBL; BC136908; AAI36909.1; -; mRNA.
DR EMBL; AF399574; AAK95059.1; -; Genomic_DNA.
DR EMBL; BK004223; DAA04621.1; -; Genomic_DNA.
DR RefSeq; NP_001004195.2; NM_001004195.2.
DR AlphaFoldDB; Q96R69; -.
DR SMR; Q96R69; -.
DR STRING; 9606.ENSP00000317482; -.
DR iPTMnet; Q96R69; -.
DR PhosphoSitePlus; Q96R69; -.
DR BioMuta; OR4F4; -.
DR DMDM; 38372849; -.
DR PaxDb; Q96R69; -.
DR PeptideAtlas; Q96R69; -.
DR PRIDE; Q96R69; -.
DR Antibodypedia; 56270; 57 antibodies from 19 providers.
DR DNASU; 26682; -.
DR Ensembl; ENST00000673169.1; ENSP00000500162.1; ENSG00000288513.1.
DR GeneID; 26682; -.
DR UCSC; uc002cdf.2; human.
DR CTD; 26682; -.
DR GeneCards; OR4F4; -.
DR HGNC; HGNC:8301; OR4F4.
DR HPA; ENSG00000177693; Not detected.
DR neXtProt; NX_Q96R69; -.
DR PharmGKB; PA32290; -.
DR VEuPathDB; HostDB:ENSG00000177693; -.
DR eggNOG; ENOG502SKZV; Eukaryota.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q96R69; -.
DR OMA; SADTIFW; -.
DR OrthoDB; 958833at2759; -.
DR PhylomeDB; Q96R69; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q96R69; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26682; 353 hits in 532 CRISPR screens.
DR GenomeRNAi; 26682; -.
DR Pharos; Q96R69; Tdark.
DR PRO; PR:Q96R69; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q96R69; protein.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..305
FT /note="Olfactory receptor 4F4"
FT /id="PRO_0000150546"
FT TOPO_DOM 1..18
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 19..42
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..50
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..72
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..113
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..151
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..188
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..212
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..228
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..251
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..262
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..282
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..305
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 90..182
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 305 AA; 34259 MW; 903D4D8E98EA07F6 CRC64;
MVTEFIFLGL SDSQELQTFL FMLFFVFYGG IVFGNLLIVI TVVSDSHLHS PMYFLLANLS
LIDLSLSSVT APKMITDFFS QRKVISFKGC LVQIFLLHFF GGSEMVILIA MGFDRYIAIC
KPLHYTTIMC GNACVGIMAV AWGIGFLHSV SQLAFAVHLP FCGPNEVDSF YCDLPRVIKL
ACTDTYRLDI MVIANSGVLT VCSFVLLIIS YTIILMTIQH CPLDKSSKAL STLTAHITVV
LLFFGPCVFI YAWPFPIKSL DKFLAVFYSV ITPLLNPIIY TLRNKDMKTA IRRLRKWDAH
SSVKF
