OR4F6_HUMAN
ID OR4F6_HUMAN Reviewed; 312 AA.
AC Q8NGB9; B9EH28; Q6IF95;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Olfactory receptor 4F6;
DE AltName: Full=Olfactory receptor 4F12;
DE AltName: Full=Olfactory receptor OR15-15;
GN Name=OR4F6; Synonyms=OR4F12;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4F6";
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DR EMBL; AB065899; BAC06115.1; -; Genomic_DNA.
DR EMBL; CH471101; EAX02319.1; -; Genomic_DNA.
DR EMBL; BC137002; AAI37003.1; -; mRNA.
DR EMBL; BC137003; AAI37004.1; -; mRNA.
DR EMBL; BK004367; DAA04765.1; -; Genomic_DNA.
DR CCDS; CCDS32341.1; -.
DR RefSeq; NP_001005326.1; NM_001005326.1.
DR AlphaFoldDB; Q8NGB9; -.
DR SMR; Q8NGB9; -.
DR STRING; 9606.ENSP00000327525; -.
DR GlyGen; Q8NGB9; 1 site.
DR BioMuta; OR4F6; -.
DR DMDM; 38372660; -.
DR PaxDb; Q8NGB9; -.
DR PeptideAtlas; Q8NGB9; -.
DR PRIDE; Q8NGB9; -.
DR Antibodypedia; 56268; 43 antibodies from 16 providers.
DR DNASU; 390648; -.
DR Ensembl; ENST00000328882.6; ENSP00000327525.4; ENSG00000184140.6.
DR GeneID; 390648; -.
DR KEGG; hsa:390648; -.
DR MANE-Select; ENST00000328882.6; ENSP00000327525.4; NM_001005326.2; NP_001005326.1.
DR UCSC; uc010utr.3; human.
DR CTD; 390648; -.
DR GeneCards; OR4F6; -.
DR HGNC; HGNC:15372; OR4F6.
DR HPA; ENSG00000184140; Not detected.
DR neXtProt; NX_Q8NGB9; -.
DR PharmGKB; PA32292; -.
DR VEuPathDB; HostDB:ENSG00000184140; -.
DR eggNOG; ENOG502T9N1; Eukaryota.
DR GeneTree; ENSGT00940000163199; -.
DR HOGENOM; CLU_012526_8_2_1; -.
DR InParanoid; Q8NGB9; -.
DR OMA; CTQFVNY; -.
DR OrthoDB; 1020343at2759; -.
DR PhylomeDB; Q8NGB9; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; Q8NGB9; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390648; 12 hits in 672 CRISPR screens.
DR GeneWiki; OR4F6; -.
DR GenomeRNAi; 390648; -.
DR Pharos; Q8NGB9; Tdark.
DR PRO; PR:Q8NGB9; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q8NGB9; protein.
DR ExpressionAtlas; Q8NGB9; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 4F6"
FT /id="PRO_0000150548"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 312 AA; 35355 MW; B4FE59A4354F681A CRC64;
MDEANHSVVS EFVFLGLSDS RKIQLLLFLF FSVFYVSSLM GNLLIVLTVT SDPRLQSPMY
FLLANLSIIN LVFCSSTAPK MIYDLFRKHK TISFGGCVVQ IFFIHAVGGT EMVLLIAMAF
DRYVAICKPL HYLTIMNPQR CILFLVISWI IGIIHSVIQL AFVVDLLFCG PNELDSFFCD
LPRFIKLACI ETYTLGFMVT ANSGFISLAS FLILIISYIF ILVTVQKKSS GGIFKAFSML
SAHVIVVVLV FGPLIFFYIF PFPTSHLDKF LAIFDAVITP VLNPVIYTFR NKEMMVAMRR
RCSQFVNYSK IF
