OR4K1_HUMAN
ID OR4K1_HUMAN Reviewed; 311 AA.
AC Q8NGD4; B9EKV9; Q8NGD6; Q96R73;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Olfactory receptor 4K1;
DE AltName: Full=Olfactory receptor OR14-19;
GN Name=OR4K1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT HIS-304.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT HIS-304.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT HIS-304.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-280.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4K1";
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DR EMBL; AB065879; BAC06097.1; -; Genomic_DNA.
DR EMBL; AB065881; BAC06099.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66494.1; -; Genomic_DNA.
DR EMBL; BC151145; AAI51146.1; -; mRNA.
DR EMBL; AF399570; AAK95055.1; -; Genomic_DNA.
DR EMBL; BK004356; DAA04754.1; -; Genomic_DNA.
DR CCDS; CCDS32025.1; -.
DR RefSeq; NP_001004063.2; NM_001004063.2.
DR RefSeq; XP_011535455.1; XM_011537153.2.
DR AlphaFoldDB; Q8NGD4; -.
DR SMR; Q8NGD4; -.
DR BioGRID; 122709; 2.
DR STRING; 9606.ENSP00000285600; -.
DR GlyGen; Q8NGD4; 1 site.
DR BioMuta; OR4K1; -.
DR DMDM; 38372674; -.
DR MassIVE; Q8NGD4; -.
DR PaxDb; Q8NGD4; -.
DR PeptideAtlas; Q8NGD4; -.
DR PRIDE; Q8NGD4; -.
DR ProteomicsDB; 73484; -.
DR Antibodypedia; 21991; 81 antibodies from 21 providers.
DR DNASU; 79544; -.
DR Ensembl; ENST00000285600.4; ENSP00000285600.3; ENSG00000155249.5.
DR Ensembl; ENST00000641172.1; ENSP00000493193.1; ENSG00000155249.5.
DR Ensembl; ENST00000641429.1; ENSP00000493205.1; ENSG00000155249.5.
DR GeneID; 79544; -.
DR KEGG; hsa:79544; -.
DR MANE-Select; ENST00000641172.1; ENSP00000493193.1; NM_001004063.3; NP_001004063.2.
DR UCSC; uc001vwj.2; human.
DR CTD; 79544; -.
DR GeneCards; OR4K1; -.
DR HGNC; HGNC:14726; OR4K1.
DR HPA; ENSG00000155249; Not detected.
DR neXtProt; NX_Q8NGD4; -.
DR PharmGKB; PA32308; -.
DR VEuPathDB; HostDB:ENSG00000155249; -.
DR eggNOG; ENOG502SK03; Eukaryota.
DR GeneTree; ENSGT00940000162669; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NGD4; -.
DR OMA; QRLCIIF; -.
DR PhylomeDB; Q8NGD4; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NGD4; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 79544; 117 hits in 670 CRISPR screens.
DR GeneWiki; OR4K1; -.
DR GenomeRNAi; 79544; -.
DR Pharos; Q8NGD4; Tdark.
DR PRO; PR:Q8NGD4; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NGD4; protein.
DR Bgee; ENSG00000155249; Expressed in gall bladder.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 4K1"
FT /id="PRO_0000150552"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 89
FT /note="R -> H (in dbSNP:rs12885778)"
FT /id="VAR_054121"
FT VARIANT 138
FT /note="R -> Q (in dbSNP:rs3916626)"
FT /id="VAR_054122"
FT VARIANT 304
FT /note="R -> H (in dbSNP:rs2792146)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1,
FT ECO:0000269|Ref.2"
FT /id="VAR_054123"
SQ SEQUENCE 311 AA; 35201 MW; 97C9A3B6DC91A063 CRC64;
MAHTNESMVS EFVLLGLSNS WGLQLFFFAI FSIVYVTSVL GNVLIIVIIS FDSHLNSPMY
FLLSNLSFID ICQSNFATPK MLVDFFIERK TISFEGCMAQ IFVLHSFVGS EMMLLVAMAY
DRFIAICKPL HYSTIMNRRL CVIFVSISWA VGVLHSVSHL AFTVDLPFCG PNEVDSFFCD
LPLVIELACM DTYEMEIMTL TNSGLISLSC FLALIISYTI ILIGVRCRSS SGSSKALSTL
TAHITVVILF FGPCIYFYIW PFSRLPVDKF LSVFYTVCTP LLNPIIYSLR NEDVKAAMWK
LRNRHVNSWK N
