OR4K2_HUMAN
ID OR4K2_HUMAN Reviewed; 314 AA.
AC Q8NGD2; B2RNK8; Q6IFA5;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 4K2;
DE AltName: Full=Olfactory receptor OR14-15;
GN Name=OR4K2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4K2";
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DR EMBL; AB065883; BAC06101.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66496.1; -; Genomic_DNA.
DR EMBL; BC136941; AAI36942.1; -; mRNA.
DR EMBL; BC136942; AAI36943.1; -; mRNA.
DR EMBL; BK004357; DAA04755.1; -; Genomic_DNA.
DR CCDS; CCDS32023.1; -.
DR RefSeq; NP_001005501.1; NM_001005501.1.
DR AlphaFoldDB; Q8NGD2; -.
DR SMR; Q8NGD2; -.
DR STRING; 9606.ENSP00000298642; -.
DR GlyGen; Q8NGD2; 1 site.
DR BioMuta; OR4K2; -.
DR DMDM; 38372672; -.
DR PaxDb; Q8NGD2; -.
DR PeptideAtlas; Q8NGD2; -.
DR PRIDE; Q8NGD2; -.
DR ProteomicsDB; 73482; -.
DR Antibodypedia; 58519; 94 antibodies from 22 providers.
DR DNASU; 390431; -.
DR Ensembl; ENST00000298642.2; ENSP00000298642.2; ENSG00000165762.3.
DR Ensembl; ENST00000641885.1; ENSP00000493007.1; ENSG00000165762.3.
DR GeneID; 390431; -.
DR KEGG; hsa:390431; -.
DR MANE-Select; ENST00000641885.1; ENSP00000493007.1; NM_001005501.2; NP_001005501.1.
DR UCSC; uc001vwh.2; human.
DR CTD; 390431; -.
DR DisGeNET; 390431; -.
DR GeneCards; OR4K2; -.
DR HGNC; HGNC:14728; OR4K2.
DR HPA; ENSG00000165762; Not detected.
DR neXtProt; NX_Q8NGD2; -.
DR PharmGKB; PA32317; -.
DR VEuPathDB; HostDB:ENSG00000165762; -.
DR eggNOG; ENOG502T0ZV; Eukaryota.
DR GeneTree; ENSGT00940000162171; -.
DR HOGENOM; CLU_012526_8_2_1; -.
DR InParanoid; Q8NGD2; -.
DR OMA; KSTMFEL; -.
DR OrthoDB; 906728at2759; -.
DR PhylomeDB; Q8NGD2; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NGD2; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390431; 11 hits in 668 CRISPR screens.
DR GeneWiki; OR4K2; -.
DR GenomeRNAi; 390431; -.
DR Pharos; Q8NGD2; Tdark.
DR PRO; PR:Q8NGD2; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NGD2; protein.
DR Bgee; ENSG00000165762; Expressed in uterine cervix.
DR ExpressionAtlas; Q8NGD2; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 4K2"
FT /id="PRO_0000150553"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 307
FT /note="N -> I (in dbSNP:rs12883767)"
FT /id="VAR_053171"
SQ SEQUENCE 314 AA; 35357 MW; 946877CDB260EC59 CRC64;
MDVGNKSTMS EFVLLGLSNS WELQMFFFMV FSLLYVATMV GNSLIVITVI VDPHLHSPMY
FLLTNLSIID MSLASFATPK MITDYLTGHK TISFDGCLTQ IFFLHLFTGT EIILLMAMSF
DRYIAICKPL HYASVISPQV CVALVVASWI MGVMHSMSQV IFALTLPFCG PYEVDSFFCD
LPVVFQLACV DTYVLGLFMI STSGIIALSC FIVLFNSYVI VLVTVKHHSS RGSSKALSTC
TAHFIVVFLF FGPCIFIYMW PLSSFLTDKI LSVFYTIFTP TLNPIIYTLR NQEVKIAMRK
LKNRFLNFNK AMPS
