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OR4K5_HUMAN
ID   OR4K5_HUMAN             Reviewed;         323 AA.
AC   Q8NGD3; Q6IFA7;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=Olfactory receptor 4K5;
DE   AltName: Full=Olfactory receptor OR14-16;
GN   Name=OR4K5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [3]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4K5";
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DR   EMBL; AB065882; BAC06100.1; -; Genomic_DNA.
DR   EMBL; BK004355; DAA04753.1; -; Genomic_DNA.
DR   CCDS; CCDS32024.1; -.
DR   RefSeq; NP_001005483.1; NM_001005483.1.
DR   AlphaFoldDB; Q8NGD3; -.
DR   SMR; Q8NGD3; -.
DR   STRING; 9606.ENSP00000319511; -.
DR   GlyGen; Q8NGD3; 1 site.
DR   BioMuta; OR4K5; -.
DR   DMDM; 38372673; -.
DR   PaxDb; Q8NGD3; -.
DR   PeptideAtlas; Q8NGD3; -.
DR   PRIDE; Q8NGD3; -.
DR   Antibodypedia; 58520; 60 antibodies from 16 providers.
DR   DNASU; 79317; -.
DR   Ensembl; ENST00000315915.5; ENSP00000319511.3; ENSG00000176281.5.
DR   GeneID; 79317; -.
DR   KEGG; hsa:79317; -.
DR   MANE-Select; ENST00000315915.5; ENSP00000319511.3; NM_001005483.1; NP_001005483.1.
DR   UCSC; uc010tkw.3; human.
DR   CTD; 79317; -.
DR   GeneCards; OR4K5; -.
DR   HGNC; HGNC:14745; OR4K5.
DR   HPA; ENSG00000176281; Not detected.
DR   neXtProt; NX_Q8NGD3; -.
DR   OpenTargets; ENSG00000176281; -.
DR   PharmGKB; PA32320; -.
DR   VEuPathDB; HostDB:ENSG00000176281; -.
DR   eggNOG; ENOG502T9M0; Eukaryota.
DR   GeneTree; ENSGT00940000163286; -.
DR   HOGENOM; CLU_012526_5_5_1; -.
DR   InParanoid; Q8NGD3; -.
DR   OMA; YTIEILI; -.
DR   OrthoDB; 1042425at2759; -.
DR   PhylomeDB; Q8NGD3; -.
DR   TreeFam; TF337251; -.
DR   PathwayCommons; Q8NGD3; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 79317; 4 hits in 664 CRISPR screens.
DR   GeneWiki; OR4K5; -.
DR   GenomeRNAi; 79317; -.
DR   Pharos; Q8NGD3; Tdark.
DR   PRO; PR:Q8NGD3; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   RNAct; Q8NGD3; protein.
DR   ExpressionAtlas; Q8NGD3; baseline and differential.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..323
FT                   /note="Olfactory receptor 4K5"
FT                   /id="PRO_0000150555"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..269
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..289
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        290..323
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         319
FT                   /note="R -> K (in dbSNP:rs17242341)"
FT                   /id="VAR_034200"
SQ   SEQUENCE   323 AA;  36258 MW;  D4EE96021A34F29A CRC64;
     MDKSNSSVVS EFVLLGLCSS QKLQLFYFCF FSVLYTVIVL GNLLIILTVT SDTSLHSPMY
     FLLGNLSFVD ICQASFATPK MIADFLSAHE TISFSGCIAQ IFFIHLFTGG EMVLLVSMAY
     DRYVAICKPL YYVVIMSRRT CTVLVMISWA VSLVHTLSQL SFTVNLPFCG PNVVDSFFCD
     LPRVTKLACL DSYIIEILIV VNSGILSLST FSLLVSSYII ILVTVWLKSS AAMAKAFSTL
     ASHIAVVILF FGPCIFIYVW PFTISPLDKF LAIFYTVFTP VLNPIIYTLR NRDMKAAVRK
     IVNHYLRPRR ISEMSLVVRT SFH
 
 
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