OR4KD_HUMAN
ID OR4KD_HUMAN Reviewed; 304 AA.
AC Q8NH42; Q6IF13;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Olfactory receptor 4K13;
DE AltName: Full=Olfactory receptor OR14-27;
GN Name=OR4K13;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4K13";
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DR EMBL; AB065559; BAC05797.1; -; Genomic_DNA.
DR EMBL; BK004449; DAA04847.1; -; Genomic_DNA.
DR CCDS; CCDS32028.1; -.
DR RefSeq; NP_001004714.1; NM_001004714.1.
DR AlphaFoldDB; Q8NH42; -.
DR SMR; Q8NH42; -.
DR STRING; 9606.ENSP00000319322; -.
DR GlyGen; Q8NH42; 1 site.
DR iPTMnet; Q8NH42; -.
DR PhosphoSitePlus; Q8NH42; -.
DR BioMuta; OR4K13; -.
DR DMDM; 38372805; -.
DR PaxDb; Q8NH42; -.
DR PeptideAtlas; Q8NH42; -.
DR PRIDE; Q8NH42; -.
DR Antibodypedia; 66262; 64 antibodies from 19 providers.
DR DNASU; 390433; -.
DR Ensembl; ENST00000641664.1; ENSP00000493405.1; ENSG00000176253.4.
DR Ensembl; ENST00000641904.1; ENSP00000492930.1; ENSG00000176253.4.
DR GeneID; 390433; -.
DR KEGG; hsa:390433; -.
DR MANE-Select; ENST00000641904.1; ENSP00000492930.1; NM_001004714.2; NP_001004714.1.
DR UCSC; uc010tkz.3; human.
DR CTD; 390433; -.
DR GeneCards; OR4K13; -.
DR HGNC; HGNC:15351; OR4K13.
DR HPA; ENSG00000176253; Not detected.
DR neXtProt; NX_Q8NH42; -.
DR PharmGKB; PA32312; -.
DR VEuPathDB; HostDB:ENSG00000176253; -.
DR eggNOG; ENOG502TF8Y; Eukaryota.
DR GeneTree; ENSGT00940000163860; -.
DR HOGENOM; CLU_012526_8_2_1; -.
DR InParanoid; Q8NH42; -.
DR OMA; TIIIYSV; -.
DR OrthoDB; 1007692at2759; -.
DR PhylomeDB; Q8NH42; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NH42; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390433; 18 hits in 675 CRISPR screens.
DR GeneWiki; OR4K13; -.
DR GenomeRNAi; 390433; -.
DR Pharos; Q8NH42; Tdark.
DR PRO; PR:Q8NH42; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NH42; protein.
DR ExpressionAtlas; Q8NH42; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..304
FT /note="Olfactory receptor 4K13"
FT /id="PRO_0000150556"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..304
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 292
FT /note="Q -> K (in dbSNP:rs17277025)"
FT /id="VAR_053172"
SQ SEQUENCE 304 AA; 34261 MW; CF943D6F010C80C9 CRC64;
MERANHSVVS EFILLGLSKS QNLQILFFLG FSVVFVGIVL GNLLILVTVT FDSLLHTPMY
FLLSNLSCID MILASFATPK MIVDFLRERK TISWWGCYSQ MFFMHLLGGS EMMLLVAMAI
DRYVAICKPL HYMTIMSPRV LTGLLLSSYA VGFVHSSSQM AFMLTLPFCG PNVIDSFFCD
LPLVIKLACK DTYILQLLVI ADSGLLSLVC FLLLLVSYGV IIFSVRYRAA SRSSKAFSTL
SAHITVVTLF FAPCVFIYVW PFSRYSVDKI LSVFYTIFTP LLNPIIYTLR NQEVKAAIKK
RLCI
