OR4KE_HUMAN
ID OR4KE_HUMAN Reviewed; 310 AA.
AC Q8NGD5; Q6IEU1; Q96R71;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Olfactory receptor 4K14;
DE AltName: Full=Olfactory receptor OR14-22;
GN Name=OR4K14;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-282.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4K14";
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DR EMBL; AB065880; BAC06098.1; -; Genomic_DNA.
DR EMBL; AF399572; AAK95057.1; -; Genomic_DNA.
DR EMBL; BK004521; DAA04919.1; -; Genomic_DNA.
DR CCDS; CCDS32027.1; -.
DR RefSeq; NP_001004712.1; NM_001004712.1.
DR AlphaFoldDB; Q8NGD5; -.
DR SMR; Q8NGD5; -.
DR STRING; 9606.ENSP00000305011; -.
DR GlyGen; Q8NGD5; 1 site.
DR PhosphoSitePlus; Q8NGD5; -.
DR BioMuta; OR4K14; -.
DR DMDM; 38372675; -.
DR PaxDb; Q8NGD5; -.
DR PeptideAtlas; Q8NGD5; -.
DR PRIDE; Q8NGD5; -.
DR ProteomicsDB; 73485; -.
DR Antibodypedia; 57315; 128 antibodies from 19 providers.
DR DNASU; 122740; -.
DR Ensembl; ENST00000641793.1; ENSP00000493106.1; ENSG00000169484.4.
DR GeneID; 122740; -.
DR KEGG; hsa:122740; -.
DR MANE-Select; ENST00000641793.1; ENSP00000493106.1; NM_001004712.2; NP_001004712.1.
DR UCSC; uc010tky.3; human.
DR CTD; 122740; -.
DR GeneCards; OR4K14; -.
DR HGNC; HGNC:15352; OR4K14.
DR HPA; ENSG00000169484; Not detected.
DR neXtProt; NX_Q8NGD5; -.
DR PharmGKB; PA32313; -.
DR VEuPathDB; HostDB:ENSG00000169484; -.
DR eggNOG; ENOG502SK03; Eukaryota.
DR GeneTree; ENSGT00940000163733; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGD5; -.
DR OMA; QNFFFIF; -.
DR OrthoDB; 903556at2759; -.
DR PhylomeDB; Q8NGD5; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NGD5; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 122740; 3 hits in 670 CRISPR screens.
DR GeneWiki; OR4K14; -.
DR GenomeRNAi; 122740; -.
DR Pharos; Q8NGD5; Tdark.
DR PRO; PR:Q8NGD5; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NGD5; protein.
DR ExpressionAtlas; Q8NGD5; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 4K14"
FT /id="PRO_0000150557"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 119
FT /note="M -> V (in dbSNP:rs7157076)"
FT /id="VAR_053173"
FT VARIANT 145
FT /note="L -> R (in dbSNP:rs17308108)"
FT /id="VAR_053174"
SQ SEQUENCE 310 AA; 35053 MW; AA7B06959BFE8E0D CRC64;
MDPQNYSLVS EFVLHGLCTS RHLQNFFFIF FFGVYVAIML GNLLILVTVI SDPCLHSSPM
YFLLGNLAFL DMWLASFATP KMIRDFLSDQ KLISFGGCMA QIFFLHFTGG AEMVLLVSMA
YDRYVAICKP LHYMTLMSWQ TCIRLVLASW VVGFVHSISQ VAFTVNLPYC GPNEVDSFFC
DLPLVIKLAC MDTYVLGIIM ISDSGLLSLS CFLLLLISYT VILLAIRQRA AGSTSKALST
CSAHIMVVTL FFGPCIFVYV RPFSRFSVDK LLSVFYTIFT PLLNPIIYTL RNEEMKAAMK
KLQNRRVTFQ
