OR4KF_HUMAN
ID OR4KF_HUMAN Reviewed; 324 AA.
AC Q8NH41; B9EIL3; Q6IEZ4;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 3.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Olfactory receptor 4K15;
DE AltName: Full=Olfactory receptor OR14-20;
GN Name=OR4K15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS SER-65; VAL-88;
RP ALA-93; GLU-231; PRO-280 AND MET-286.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI40727.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=DAA04866.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4K15";
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DR EMBL; AB065560; BAC05798.1; -; Genomic_DNA.
DR EMBL; AL359218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC140726; AAI40727.1; ALT_INIT; mRNA.
DR EMBL; BK004468; DAA04866.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS32026.1; -.
DR RefSeq; NP_001005486.1; NM_001005486.1.
DR AlphaFoldDB; Q8NH41; -.
DR STRING; 9606.ENSP00000304077; -.
DR GlyGen; Q8NH41; 2 sites.
DR iPTMnet; Q8NH41; -.
DR PhosphoSitePlus; Q8NH41; -.
DR BioMuta; OR4K15; -.
DR DMDM; 229462931; -.
DR PaxDb; Q8NH41; -.
DR PRIDE; Q8NH41; -.
DR ProteomicsDB; 73654; -.
DR Antibodypedia; 57314; 8 antibodies from 8 providers.
DR DNASU; 81127; -.
DR Ensembl; ENST00000305051.6; ENSP00000304077.5; ENSG00000169488.7.
DR GeneID; 81127; -.
DR KEGG; hsa:81127; -.
DR MANE-Select; ENST00000305051.6; ENSP00000304077.5; NM_001005486.2; NP_001005486.2.
DR UCSC; uc010tkx.3; human.
DR CTD; 81127; -.
DR GeneCards; OR4K15; -.
DR HGNC; HGNC:15353; OR4K15.
DR HPA; ENSG00000169488; Not detected.
DR neXtProt; NX_Q8NH41; -.
DR PharmGKB; PA32314; -.
DR VEuPathDB; HostDB:ENSG00000169488; -.
DR eggNOG; ENOG502R8S7; Eukaryota.
DR GeneTree; ENSGT00940000159214; -.
DR HOGENOM; CLU_012526_8_2_1; -.
DR InParanoid; Q8NH41; -.
DR OrthoDB; 1007712at2759; -.
DR PhylomeDB; Q8NH41; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NH41; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 81127; 11 hits in 664 CRISPR screens.
DR GeneWiki; OR4K15; -.
DR GenomeRNAi; 81127; -.
DR Pharos; Q8NH41; Tdark.
DR PRO; PR:Q8NH41; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NH41; protein.
DR Bgee; ENSG00000169488; Expressed in reproductive system and 4 other tissues.
DR ExpressionAtlas; Q8NH41; differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..324
FT /note="Olfactory receptor 4K15"
FT /id="PRO_0000150558"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..324
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 65
FT /note="N -> S (in dbSNP:rs4060024)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_055060"
FT VARIANT 88
FT /note="E -> V (in dbSNP:rs3861512)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_055061"
FT VARIANT 93
FT /note="S -> A (in dbSNP:rs3861513)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_055062"
FT VARIANT 231
FT /note="A -> E (in dbSNP:rs10135246)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_055063"
FT VARIANT 280
FT /note="L -> P (in dbSNP:rs2153466)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_055064"
FT VARIANT 286
FT /note="I -> M (in dbSNP:rs10135467)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_055065"
SQ SEQUENCE 324 AA; 36484 MW; 76AC2F465AA07A9F CRC64;
MNETNHSRVT EFVLLGLSSS RELQPFLFLT FSLLYLAILL GNFLIILTVT SDSRLHTPMY
FLLANLSFID VCVASFATPK MIADFLVERK TISFDACLAQ IFFVHLFTGS EMVLLVSMAY
DRYVAICKPL HYMTVMSRRV CVVLVLISWF VGFIHTTSQL AFTVNLPFCG PNKVDSFFCD
LPLVTKLACI DTYVVSLLIV ADSGFLSLSS FLLLVVSYTV ILVTVRNRSS ASMAKARSTL
TAHITVVTLF FGPCIFIYVW PFSSYSVDKV LAVFYTIFTL ILNPVIYTLR NKEVKAAMSK
LKSRYLKPSQ VSVVIRNVLF LETK
