OR4KH_HUMAN
ID OR4KH_HUMAN Reviewed; 315 AA.
AC Q8NGC6; Q6IF12;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Olfactory receptor 4K17;
DE AltName: Full=Olfactory receptor OR14-29;
GN Name=OR4K17;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA04848.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4K17";
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DR EMBL; AB065891; BAC06107.1; -; Genomic_DNA.
DR EMBL; AL163152; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004450; DAA04848.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_001004715.1; NM_001004715.1.
DR AlphaFoldDB; Q8NGC6; -.
DR SMR; Q8NGC6; -.
DR BioGRID; 133563; 1.
DR IntAct; Q8NGC6; 1.
DR STRING; 9606.ENSP00000319197; -.
DR GlyGen; Q8NGC6; 2 sites.
DR iPTMnet; Q8NGC6; -.
DR PhosphoSitePlus; Q8NGC6; -.
DR BioMuta; OR4K17; -.
DR DMDM; 229462954; -.
DR PaxDb; Q8NGC6; -.
DR PeptideAtlas; Q8NGC6; -.
DR PRIDE; Q8NGC6; -.
DR Antibodypedia; 63908; 40 antibodies from 17 providers.
DR DNASU; 390436; -.
DR Ensembl; ENST00000641386.2; ENSP00000493449.2; ENSG00000176230.7.
DR Ensembl; ENST00000641633.2; ENSP00000493115.2; ENSG00000176230.7.
DR GeneID; 390436; -.
DR KEGG; hsa:390436; -.
DR UCSC; uc001vwo.1; human.
DR CTD; 390436; -.
DR GeneCards; OR4K17; -.
DR HGNC; HGNC:15355; OR4K17.
DR HPA; ENSG00000176230; Tissue enhanced (bone marrow, liver).
DR neXtProt; NX_Q8NGC6; -.
DR VEuPathDB; HostDB:ENSG00000176230; -.
DR eggNOG; ENOG502RMP4; Eukaryota.
DR HOGENOM; CLU_012526_8_2_1; -.
DR InParanoid; Q8NGC6; -.
DR OrthoDB; 951274at2759; -.
DR PhylomeDB; Q8NGC6; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NGC6; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGC6; -.
DR BioGRID-ORCS; 390436; 11 hits in 670 CRISPR screens.
DR GeneWiki; OR4K17; -.
DR GenomeRNAi; 390436; -.
DR Pharos; Q8NGC6; Tdark.
DR PRO; PR:Q8NGC6; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NGC6; protein.
DR Bgee; ENSG00000176230; Expressed in liver.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..315
FT /note="Olfactory receptor 4K17"
FT /id="PRO_0000150559"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..82
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..123
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..222
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..315
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 267
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 100..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 315 AA; 35312 MW; F72BEFFAC1C4E2F6 CRC64;
MEAMKLLNQS QVSEFILLGL TSSQDVEFLL FALFSVIYVV TVLGNLLIIV TVFNTPNLNT
PMYFLLGNLS FVDMTLASFA TPKVILNLLK KQKVISFAGC FTQIFLLHLL GGVEMVLLVS
MAFDRYVAIC KPLHYMTIMN KKVCVLLVVT SWLLGLLHSG FQIPFAVNLP FCGPNVVDSI
FCDLPLVTKL ACIDIYFVQV VIVANSGIIS LSCFIILLIS YSLILITIKN HSPTGQSKAR
STLTAHITVV ILFFGPCIFI YIWPFGNHSV DKFLAVFYTI ITPILNPIIY TLRNKEMKIS
MKKLWRAFVN SREDT
