OR4L1_HUMAN
ID OR4L1_HUMAN Reviewed; 312 AA.
AC Q8NH43; Q6IEZ5;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Olfactory receptor 4L1;
DE AltName: Full=Olfactory receptor 4L2;
DE AltName: Full=Olfactory receptor OR14-28;
GN Name=OR4L1; Synonyms=OR4L2P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4L1";
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DR EMBL; AB065558; BAC05796.1; -; Genomic_DNA.
DR EMBL; BK004467; DAA04865.1; -; Genomic_DNA.
DR CCDS; CCDS32029.1; -.
DR RefSeq; NP_001004717.1; NM_001004717.1.
DR AlphaFoldDB; Q8NH43; -.
DR SMR; Q8NH43; -.
DR BioGRID; 125791; 1.
DR STRING; 9606.ENSP00000319217; -.
DR GlyGen; Q8NH43; 2 sites.
DR iPTMnet; Q8NH43; -.
DR PhosphoSitePlus; Q8NH43; -.
DR BioMuta; OR4L1; -.
DR DMDM; 38372806; -.
DR PaxDb; Q8NH43; -.
DR PeptideAtlas; Q8NH43; -.
DR PRIDE; Q8NH43; -.
DR TopDownProteomics; Q8NH43; -.
DR Antibodypedia; 57317; 108 antibodies from 20 providers.
DR DNASU; 122742; -.
DR Ensembl; ENST00000315683.1; ENSP00000319217.1; ENSG00000176246.1.
DR GeneID; 122742; -.
DR KEGG; hsa:122742; -.
DR MANE-Select; ENST00000315683.1; ENSP00000319217.1; NM_001004717.1; NP_001004717.1.
DR UCSC; uc001vwn.1; human.
DR CTD; 122742; -.
DR GeneCards; OR4L1; -.
DR HGNC; HGNC:15356; OR4L1.
DR HPA; ENSG00000176246; Not detected.
DR neXtProt; NX_Q8NH43; -.
DR PharmGKB; PA32325; -.
DR VEuPathDB; HostDB:ENSG00000176246; -.
DR eggNOG; ENOG502TDFF; Eukaryota.
DR GeneTree; ENSGT00940000163035; -.
DR HOGENOM; CLU_012526_8_2_1; -.
DR InParanoid; Q8NH43; -.
DR OMA; MQGAMRK; -.
DR OrthoDB; 924064at2759; -.
DR PhylomeDB; Q8NH43; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; Q8NH43; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 122742; 9 hits in 667 CRISPR screens.
DR GeneWiki; OR4L1; -.
DR GenomeRNAi; 122742; -.
DR Pharos; Q8NH43; Tdark.
DR PRO; PR:Q8NH43; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NH43; protein.
DR Bgee; ENSG00000176246; Expressed in fundus of stomach and 5 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 4L1"
FT /id="PRO_0000150560"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 268
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 2
FT /note="D -> N (in dbSNP:rs1958715)"
FT /id="VAR_034201"
FT VARIANT 16
FT /note="G -> V (in dbSNP:rs45584133)"
FT /id="VAR_062036"
FT VARIANT 40
FT /note="M -> V (in dbSNP:rs1958716)"
FT /id="VAR_034202"
FT VARIANT 52
FT /note="R -> S (in dbSNP:rs1959630)"
FT /id="VAR_024094"
FT VARIANT 93
FT /note="S -> F (in dbSNP:rs10139756)"
FT /id="VAR_034203"
FT VARIANT 101
FT /note="M -> K (in dbSNP:rs2775253)"
FT /id="VAR_034204"
FT VARIANT 109
FT /note="G -> S (in dbSNP:rs2775254)"
FT /id="VAR_034205"
FT VARIANT 160
FT /note="I -> T (in dbSNP:rs45585336)"
FT /id="VAR_062037"
SQ SEQUENCE 312 AA; 35264 MW; C7BFE135301F56F1 CRC64;
MDLKNGSLVT EFILLGFFGR WELQIFFFVT FSLIYGATVM GNILIMVTVT CRSTLHSPLY
FLLGNLSFLD MCLSTATTPK MIIDLLTDHK TISVWGCVTQ MFFMHFFGGA EMTLLIIMAF
DRYVAICKPL HYRTIMSHKL LKGFAILSWI IGFLHSISQI VLTMNLPFCG HNVINNIFCD
LPLVIKLACI ETYTLELFVI ADSGLLSFTC FILLLVSYIV ILVSVPKKSS HGLSKALSTL
SAHIIVVTLF FGPCIFIYVW PFSSLASNKT LAVFYTVITP LLNPSIYTLR NKKMQEAIRK
LRFQYVSSAQ NF
