ID   A2MGH_ECO57             Reviewed;        1534 AA.
AC   Q8XE35;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Alpha-2-macroglobulin homolog {ECO:0000305};
DE   Flags: Precursor;
GN   Name=yfaS; OrderedLocusNames=Z3481, ECs3111;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000305}.
CC   -!- CAUTION: Lacks the conserved thioester bond that is characteristic of
CC       the alpha-2-macroglobulins. {ECO:0000305}.
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DR   EMBL; AE005174; AAG57357.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB36534.1; -; Genomic_DNA.
DR   PIR; A85862; A85862.
DR   PIR; G91017; G91017.
DR   RefSeq; NP_311138.1; NC_002695.1.
DR   AlphaFoldDB; Q8XE35; -.
DR   SMR; Q8XE35; -.
DR   STRING; 155864.EDL933_3389; -.
DR   MEROPS; I39.008; -.
DR   EnsemblBacteria; AAG57357; AAG57357; Z3481.
DR   EnsemblBacteria; BAB36534; BAB36534; ECs_3111.
DR   GeneID; 916819; -.
DR   KEGG; ece:Z3481; -.
DR   KEGG; ecs:ECs_3111; -.
DR   PATRIC; fig|386585.9.peg.3245; -.
DR   eggNOG; COG2373; Bacteria.
DR   HOGENOM; CLU_004561_0_0_6; -.
DR   OMA; YAYYADW; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF01835; MG2; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SUPFAM; SSF48239; SSF48239; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal.
FT   SIGNAL          1..38
FT                   /evidence="ECO:0000255"
FT   CHAIN           39..1534
FT                   /note="Alpha-2-macroglobulin homolog"
FT                   /id="PRO_0000036240"
SQ   SEQUENCE   1534 AA;  169893 MW;  E326FD052770F1A3 CRC64;
     MDTQRFQSQF HWHLSFKFSG AIAACLSLSL VGTGLANADD SLPSSNYAPP AGGTFFLLAD
     SSFSSSEESK VRLEAPGRDY RRYQMEEYGG VDVRLYRIPD PMAFLRQQKN LHRIVVQPQY
     LGDGLNNTLT WLWDNWYGKS RRVMQRTFSS QSRQNVTQAL PELQLGNAII KPSRYVQNNQ
     FSPLKKYPLV EQFRYPLWQA KPVEPQQGVK LEGASSNFIS PQPGNIYIPL GQQEPGLYLV
     EAMVGGYRAT TVVFVSDTVA LSKVSGKELL VWTAGKKQGE AKPGSEILWT DGLGVMTRGV
     TDDSGTLQLQ HISPERSYIL GKDAEGGVFV SENFFYESEI YNTRLYIFTD RPLYRAGDRV
     DVKVMGREFH DPLHSSPIVS APAKLSVLDA NGSLLQTVDV TLDARNGGQG SFRLPENAVA
     GGYELRLAYR NQVYSSSFRV ANYIKPHFEI GLALDKKEFK TGEAVSGKLQ LLYPDGEPVK
     NARVQLSLRA QQLSMVGNDL RYAGRFPVSL EGSETVSDAS GHVALNLPAA DKPSRYLLTV
     SASDGAAYRV TTTKEILIER GLAHYSLSTA AQYSNSGESV VFRYAALESS KQVPVTYEWL
     RLEDRTSHSG DLPSGGKSFT VNFDKPGNYN LTLRDKDGLI LAGLSHAVSG KGSMSHTGTV
     DIVADKTLYQ PGETAKMLIT FPEPIDEALL TLERDRVEQQ SLLSHPANWL TLQRLNDTQY
     EARVPVSNSF APNITFSVLY TRNGQYSFQN AGIKVAVPQL DIRVKTDKTH YQPGELVNVE
     LTSSLKGKPV SAQLTVGVVD EMIYALQPEI APNIGKFFYP LGRNNVRTSS SLSFISYDQA
     LSSEPVAPGA TNRSERRVKM LERPRREEVD TAAWMPSLTT DKQGKAYFTF LMPDSLTRWR
     ITARGMNGDG LVGQGRAYLR SEKNLYMKWS MPTVYRVGDK PSAGLFIFSQ QDNEPVALVT
     KFAGAEMRQT LTLHKGANYI SLAQNIQQSG LLSAELQQNG QVQDSISTKL SFVDNSWPVE
     QQKNVMLGGG DNALMLPEQA SNIRLQSSET PQEIFRNNLD ALVDEPWGGV INTGSRLIPL
     SLAWRSLADH QSAAANDIRQ MIQDNRLRLM QLAGPGARFT WWGEDGNGDA FLTAWAWYAD
     WQASQALGVT QQPEYWQHML DSYAEQADNM PLLHRALVLA WAQEMNLPCK TLLKGLDEAI
     ARRGTKTEDF SEEDTRDIND SLILDTPESP LADAVANVLT MTLLKKAQLK STVMPQVQQY
     AWDKAVNSNQ PLAHTVVLLN SGGDATQAAA ILSGLTAEQS TIERALAMNW LAKYMATMPS
     VVLPAPAGAW AKHKLTGGGE YWRWVGQGVP DILSFGDELS PQNVQVRWRE AAKTAQQSNI
     PVTVERQLYR LIPGEEEMSF TLQPVTSNEI DSDALYLDEI TLTSEQDAVL RYGQVEVPLP
     PGADVERTTW GISVNKPNAG KQQGQLLEKA RNEMGELAYM VPVKELTGTV TFRHLLRFSQ
     KGQFVLPPAR YVRSYAPAQQ SVAAGSEWTG MQVK