ID   ASA1_YEAS8              Reviewed;         443 AA.
AC   C8ZJB0;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 2.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=ASTRA-associated protein 1;
GN   Name=ASA1; ORFNames=EC1118_1P2_4093g;
OS   Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's
OS   yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=643680;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lalvin EC1118 / Prise de mousse;
RX   PubMed=19805302; DOI=10.1073/pnas.0904673106;
RA   Novo M., Bigey F., Beyne E., Galeote V., Gavory F., Mallet S., Cambon B.,
RA   Legras J.-L., Wincker P., Casaregola S., Dequin S.;
RT   "Eukaryote-to-eukaryote gene transfer events revealed by the genome
RT   sequence of the wine yeast Saccharomyces cerevisiae EC1118.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:16333-16338(2009).
CC   -!- FUNCTION: Component of the ASTRA complex involved in chromatin
CC       remodeling. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ASTRA chromatin remodeling machinery complex
CC       composed of at least RVB1, RVB2, TRA1, TEL2, TTI1 and TTI2.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat ASA1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAY87041.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FN394217; CAY87041.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; C8ZJB0; -.
DR   EnsemblFungi; CAY87041; CAY87041; EC1118_1P2_4093g.
DR   HOGENOM; CLU_045414_1_0_1; -.
DR   Proteomes; UP000000286; Chromosome XVI, Scaffold EC1118_1P2.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Nucleus; Repeat; WD repeat.
FT   CHAIN           1..443
FT                   /note="ASTRA-associated protein 1"
FT                   /id="PRO_0000402228"
FT   REPEAT          23..67
FT                   /note="WD 1"
FT   REPEAT          71..110
FT                   /note="WD 2"
FT   REPEAT          258..295
FT                   /note="WD 3"
FT   REPEAT          318..359
FT                   /note="WD 4"
FT   REGION          372..391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   443 AA;  50563 MW;  2EF7AC0A161DED82 CRC64;
     MRGFSNEIIL KRTLTLSDFT LRYHKRGITA LQVIKAPSVS NVPVLLSGDN YGYFVMWDLV
     TKRPITHIEI EGNSHIIAFW WVETTNVLYI LSKDSMLRIF ELDSSTQLSI DLVRKLSQAN
     KTDHLQWTKI YEMPINTLNF ANFIIEAEVK PTKDNKSYRL VCCHTDDSET IDIYQIIEDS
     TFKLKRPFNN INFPRFLKQQ NFLGISKDSK FGIIMRFAKL NDVIFLGYEN GFVVGFKITF
     DEGLQRDIAE LVHVSNDHYP NPILDMCVSG DELYSCSTDD FITKYKIPVN LQLETKYLRD
     DALLIKCPSS LRVSEPSKVH LPLKNIGHID KVKDDYLVVS SWSGMTIVYN MRTSEVEQTF
     VKSKNNLVVS DSSMGDLTNG SGSNTESSSK SHNYKVGAMT CLESFDVQSD GLRLGQLRRI
     KALAKCNWCL IGYEDGTIKL NKI