OR4M1_HUMAN
ID OR4M1_HUMAN Reviewed; 313 AA.
AC Q8NGD0; B9EH18; Q6IFA3;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Olfactory receptor 4M1 {ECO:0000303|PubMed:31230984};
DE AltName: Full=Olfactory receptor OR14-7;
GN Name=OR4M1 {ECO:0000303|PubMed:31230984, ECO:0000312|HGNC:HGNC:14735};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=31230984; DOI=10.1016/j.cmet.2019.05.022;
RA Li E., Shan H., Chen L., Long A., Zhang Y., Liu Y., Jia L., Wei F., Han J.,
RA Li T., Liu X., Deng H., Wang Y.;
RT "OLFR734 mediates glucose metabolism as a receptor of asprosin.";
RL Cell Metab. 30:319-328(2019).
CC -!- FUNCTION: Olfactory receptor that acts as a receptor of Asprosin
CC hormone at the surface of hepatocytes to promote hepatocyte glucose
CC release (PubMed:31230984). Also binds Asprosin in the arcuate nucleus
CC of the hypothalamus, thereby stimulating appetite by promoting
CC orexigenic AgRP neuronal activity (By similarity). In testis, Asprosin-
CC binding promotes sperm progressive motility and enhances male fertility
CC (By similarity). The activity of this receptor is mediated by G
CC proteins which activate adenylyl cyclase, resulting in an elevation of
CC intracellular cAMP (By similarity). {ECO:0000250|UniProtKB:Q8VFT4,
CC ECO:0000269|PubMed:31230984}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31230984};
CC Multi-pass membrane protein {ECO:0000255|RuleBase:RU363047}.
CC -!- TISSUE SPECIFICITY: Highly expressed in the testis and olfactory bulb.
CC {ECO:0000269|PubMed:31230984}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4M1";
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DR EMBL; AB065886; BAC06103.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66499.1; -; Genomic_DNA.
DR EMBL; BC136987; AAI36988.1; -; mRNA.
DR EMBL; BK004359; DAA04757.1; -; Genomic_DNA.
DR CCDS; CCDS32021.1; -.
DR RefSeq; NP_001005500.1; NM_001005500.1.
DR AlphaFoldDB; Q8NGD0; -.
DR SMR; Q8NGD0; -.
DR STRING; 9606.ENSP00000319654; -.
DR GlyGen; Q8NGD0; 1 site.
DR BioMuta; OR4M1; -.
DR DMDM; 38372670; -.
DR PaxDb; Q8NGD0; -.
DR PeptideAtlas; Q8NGD0; -.
DR PRIDE; Q8NGD0; -.
DR Antibodypedia; 67688; 76 antibodies from 18 providers.
DR DNASU; 441670; -.
DR Ensembl; ENST00000315957.4; ENSP00000319654.4; ENSG00000176299.5.
DR Ensembl; ENST00000641200.1; ENSP00000492985.1; ENSG00000176299.5.
DR GeneID; 441670; -.
DR KEGG; hsa:441670; -.
DR MANE-Select; ENST00000641200.1; ENSP00000492985.1; NM_001005500.2; NP_001005500.1.
DR UCSC; uc010tku.3; human.
DR CTD; 441670; -.
DR GeneCards; OR4M1; -.
DR HGNC; HGNC:14735; OR4M1.
DR HPA; ENSG00000176299; Not detected.
DR neXtProt; NX_Q8NGD0; -.
DR PharmGKB; PA32327; -.
DR VEuPathDB; HostDB:ENSG00000176299; -.
DR eggNOG; ENOG502SKDS; Eukaryota.
DR GeneTree; ENSGT00940000163142; -.
DR HOGENOM; CLU_012526_8_2_1; -.
DR InParanoid; Q8NGD0; -.
DR OMA; MNRHLCC; -.
DR OrthoDB; 980902at2759; -.
DR PhylomeDB; Q8NGD0; -.
DR TreeFam; TF338273; -.
DR PathwayCommons; Q8NGD0; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 441670; 8 hits in 584 CRISPR screens.
DR GeneWiki; OR4M1; -.
DR GenomeRNAi; 441670; -.
DR Pharos; Q8NGD0; Tdark.
DR PRO; PR:Q8NGD0; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NGD0; protein.
DR Bgee; ENSG00000176299; Expressed in right testis and 2 other tissues.
DR ExpressionAtlas; Q8NGD0; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IDA:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 4M1"
FT /id="PRO_0000150561"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 116
FT /note="T -> I (in dbSNP:rs2635535)"
FT /id="VAR_034206"
FT VARIANT 232
FT /note="G -> D (in dbSNP:rs2815960)"
FT /id="VAR_048031"
SQ SEQUENCE 313 AA; 35488 MW; 580CEDBB4E30367E CRC64;
METANYTKVT EFVLTGLSQT REVQLVLFVI FLSFYLFILP GNILIICTIR LDPHLTSPMY
FLLANLALLD IWYSSITAPK MLIDFFVERK IISFGGCIAQ LFFLHFVGAS EMFLLTVMAY
DRYAAICRPL HYATIMNRRL CCILVALSWM GGFIHSIIQV ALIVRLPFCG PNELDSYFCD
ITQVVRIACA NTFPEELVMI CSSGLISVVC FIALLMSYAF LLALLKKHSG SGENTNRAMS
TCYSHITIVV LMFGPSIYIY ARPFDSFSLD KVVSVFHTVI FPLLNPIIYT LRNKEVKAAM
RKVVTKYILC EEK
