OR4M2_HUMAN
ID OR4M2_HUMAN Reviewed; 313 AA.
AC Q8NGB6; B9EH16; Q6IEY2;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Olfactory receptor 4M2;
DE AltName: Full=Olfactory receptor OR15-3;
GN Name=OR4M2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LEU-225.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLU-96 AND LEU-225.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4M2";
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DR EMBL; AB065903; BAC06118.1; -; Genomic_DNA.
DR EMBL; AC134980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136985; AAI36986.1; -; mRNA.
DR EMBL; BK004480; DAA04878.1; -; Genomic_DNA.
DR CCDS; CCDS32172.1; -.
DR RefSeq; NP_001004719.2; NM_001004719.2.
DR AlphaFoldDB; Q8NGB6; -.
DR SMR; Q8NGB6; -.
DR STRING; 9606.ENSP00000483239; -.
DR GlyGen; Q8NGB6; 1 site.
DR BioMuta; OR4M2; -.
DR DMDM; 311033407; -.
DR PaxDb; Q8NGB6; -.
DR PRIDE; Q8NGB6; -.
DR Antibodypedia; 72861; 57 antibodies from 13 providers.
DR DNASU; 390538; -.
DR Ensembl; ENST00000614722.3; ENSP00000483239.1; ENSG00000274102.3.
DR GeneID; 390538; -.
DR KEGG; hsa:390538; -.
DR MANE-Select; ENST00000614722.3; ENSP00000483239.1; NM_001004719.2; NP_001004719.2.
DR UCSC; uc010tzu.3; human.
DR CTD; 390538; -.
DR GeneCards; OR4M2; -.
DR HGNC; HGNC:15373; OR4M2.
DR HPA; ENSG00000274102; Not detected.
DR neXtProt; NX_Q8NGB6; -.
DR OpenTargets; ENSG00000274102; -.
DR PharmGKB; PA32328; -.
DR VEuPathDB; HostDB:ENSG00000274102; -.
DR eggNOG; ENOG502SKDS; Eukaryota.
DR GeneTree; ENSGT00940000163142; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGB6; -.
DR OrthoDB; 980902at2759; -.
DR PhylomeDB; Q8NGB6; -.
DR TreeFam; TF338273; -.
DR PathwayCommons; Q8NGB6; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390538; 16 hits in 595 CRISPR screens.
DR GeneWiki; OR4M2; -.
DR GenomeRNAi; 390538; -.
DR Pharos; Q8NGB6; Tdark.
DR PRO; PR:Q8NGB6; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q8NGB6; protein.
DR Bgee; ENSG00000274102; Expressed in left testis and 5 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 4M2"
FT /id="PRO_0000150562"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 96
FT /note="G -> E (in dbSNP:rs1835183)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_047831"
FT VARIANT 121
FT /note="D -> N (in dbSNP:rs11857531)"
FT /id="VAR_047832"
FT VARIANT 225
FT /note="F -> L (in dbSNP:rs491208)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_047833"
FT VARIANT 239
FT /note="M -> V (in dbSNP:rs12593418)"
FT /id="VAR_047834"
FT VARIANT 284
FT /note="R -> H (in dbSNP:rs4087943)"
FT /id="VAR_047835"
SQ SEQUENCE 313 AA; 35416 MW; C64ADE94D1F97533 CRC64;
METANYTKVT EFVLTGLSQT PEVQLVLFVI FLSFYLFILP GNILIICTIS LDPHLTSPMY
FLLANLAFLD IWYSSITAPE MLIDFFVERK IISFDGCIAQ LFFLHFAGAS EMFLLTVMAF
DLYTAICRPL HYATIMNQRL CCILVALSWR GGFIHSIIQV ALIVRLPFCG PNELDSYFCD
ITQVVRIACA NTFPEELVMI CSSGLISVVC LIALLMSYAF LLALFKKLSG SGENTNRAMS
TCYSHITIVV LMFGPSIYIY ARPFDSFSLD KVVSVFNTLI FPLRNPIIYT LRNKEVKAAM
RKLVTKYILC KEK
