OR4N2_HUMAN
ID OR4N2_HUMAN Reviewed; 307 AA.
AC Q8NGD1; Q6IEY9; Q6IFA2;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Olfactory receptor 4N2;
DE AltName: Full=Olfactory receptor OR14-13;
DE AltName: Full=Olfactory receptor OR14-8;
GN Name=OR4N2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4N2";
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DR EMBL; AB065885; BAC06102.1; -; Genomic_DNA.
DR EMBL; BK004473; DAA04871.1; -; Genomic_DNA.
DR EMBL; BK004360; DAA04758.1; -; Genomic_DNA.
DR CCDS; CCDS32022.1; -.
DR RefSeq; NP_001004723.1; NM_001004723.2.
DR AlphaFoldDB; Q8NGD1; -.
DR SMR; Q8NGD1; -.
DR BioGRID; 133557; 36.
DR IntAct; Q8NGD1; 1.
DR STRING; 9606.ENSP00000319601; -.
DR GlyGen; Q8NGD1; 1 site.
DR iPTMnet; Q8NGD1; -.
DR PhosphoSitePlus; Q8NGD1; -.
DR BioMuta; OR4N2; -.
DR DMDM; 38372671; -.
DR PaxDb; Q8NGD1; -.
DR PeptideAtlas; Q8NGD1; -.
DR PRIDE; Q8NGD1; -.
DR Antibodypedia; 58514; 81 antibodies from 19 providers.
DR DNASU; 390429; -.
DR Ensembl; ENST00000315947.1; ENSP00000319601.1; ENSG00000176294.6.
DR Ensembl; ENST00000557677.3; ENSP00000452022.2; ENSG00000176294.6.
DR Ensembl; ENST00000641240.1; ENSP00000493327.1; ENSG00000176294.6.
DR GeneID; 390429; -.
DR KEGG; hsa:390429; -.
DR MANE-Select; ENST00000557677.3; ENSP00000452022.2; NM_001004723.3; NP_001004723.1.
DR UCSC; uc010tkv.2; human.
DR CTD; 390429; -.
DR GeneCards; OR4N2; -.
DR HGNC; HGNC:14742; OR4N2.
DR HPA; ENSG00000176294; Tissue enriched (testis).
DR neXtProt; NX_Q8NGD1; -.
DR PharmGKB; PA32330; -.
DR VEuPathDB; HostDB:ENSG00000176294; -.
DR eggNOG; ENOG502SKDS; Eukaryota.
DR GeneTree; ENSGT00940000163357; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGD1; -.
DR OMA; MEYENST; -.
DR OrthoDB; 1130067at2759; -.
DR PhylomeDB; Q8NGD1; -.
DR TreeFam; TF338273; -.
DR PathwayCommons; Q8NGD1; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGD1; -.
DR BioGRID-ORCS; 390429; 104 hits in 639 CRISPR screens.
DR ChiTaRS; OR4N2; human.
DR GeneWiki; OR4N2; -.
DR GenomeRNAi; 390429; -.
DR Pharos; Q8NGD1; Tdark.
DR PRO; PR:Q8NGD1; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NGD1; protein.
DR Bgee; ENSG00000176294; Expressed in testis and 11 other tissues.
DR ExpressionAtlas; Q8NGD1; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..307
FT /note="Olfactory receptor 4N2"
FT /id="PRO_0000150563"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..307
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 76
FT /note="I -> T (in dbSNP:rs2801164)"
FT /id="VAR_048032"
FT VARIANT 133
FT /note="P -> S (in dbSNP:rs2318279)"
FT /id="VAR_048033"
FT VARIANT 135
FT /note="V -> L (in dbSNP:rs17114261)"
FT /id="VAR_034207"
SQ SEQUENCE 307 AA; 34721 MW; 69BB9360CCC590B5 CRC64;
MESENRTVIR EFILLGLTQS QDIQLLVFVL VLIFYFIILP GNFLIIFTIK SDPGLTAPLY
FFLGNLAFLD ASYSFIVAPR MLVDFLSAKK IISYRGCITQ LFFLHFLGGG EGLLLVVMAF
DRYIAICRPL HYPTVMNPRT CYAMMLALWL GGFVHSIIQV VLILRLPFCG PNQLDNFFCD
VPQVIKLACT DTFVVELLMV FNSGLMTLLC FLGLLASYAV ILCRIRGSSS EAKNKAMSTC
ITHIIVIFFM FGPGIFIYTR PFRAFPADKV VSLFHTVIFP LLNPVIYTLR NQEVKASMKK
VFNKHIA
