OR4N4_HUMAN
ID OR4N4_HUMAN Reviewed; 316 AA.
AC Q8N0Y3; Q6IEY3; Q6IF56;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Olfactory receptor 4N4;
DE AltName: Full=Olfactory receptor OR15-1;
DE AltName: Full=Olfactory receptor OR15-5;
GN Name=OR4N4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS PHE-61; PHE-86 AND MET-239.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4N4";
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DR EMBL; AB065653; BAC05879.1; -; Genomic_DNA.
DR EMBL; AB065904; BAC06119.1; -; Genomic_DNA.
DR EMBL; CH878499; EAW50561.1; -; Genomic_DNA.
DR EMBL; BC136597; AAI36598.1; -; mRNA.
DR EMBL; BC136598; AAI36599.1; -; mRNA.
DR EMBL; BK004406; DAA04804.1; -; Genomic_DNA.
DR EMBL; BK004479; DAA04877.1; -; Genomic_DNA.
DR CCDS; CCDS32173.1; -.
DR RefSeq; NP_001005241.2; NM_001005241.3.
DR RefSeq; XP_011544524.1; XM_011546222.1.
DR RefSeq; XP_011544526.1; XM_011546224.2.
DR RefSeq; XP_016885604.1; XM_017030115.1.
DR RefSeq; XP_016885605.1; XM_017030116.1.
DR RefSeq; XP_016885606.1; XM_017030117.1.
DR RefSeq; XP_016885607.1; XM_017030118.1.
DR AlphaFoldDB; Q8N0Y3; -.
DR SMR; Q8N0Y3; -.
DR BioGRID; 129649; 17.
DR STRING; 9606.ENSP00000332500; -.
DR GlyGen; Q8N0Y3; 1 site.
DR iPTMnet; Q8N0Y3; -.
DR PhosphoSitePlus; Q8N0Y3; -.
DR BioMuta; OR4N4; -.
DR DMDM; 218511730; -.
DR PaxDb; Q8N0Y3; -.
DR PeptideAtlas; Q8N0Y3; -.
DR PRIDE; Q8N0Y3; -.
DR Antibodypedia; 65186; 82 antibodies from 18 providers.
DR DNASU; 283694; -.
DR Ensembl; ENST00000328795.5; ENSP00000332500.4; ENSG00000183706.5.
DR GeneID; 102723532; -.
DR GeneID; 283694; -.
DR KEGG; hsa:283694; -.
DR MANE-Select; ENST00000328795.6; ENSP00000332500.4; NM_001005241.4; NP_001005241.2.
DR UCSC; uc010tzv.3; human.
DR CTD; 283694; -.
DR GeneCards; OR4N4; -.
DR HGNC; HGNC:15375; OR4N4.
DR HPA; ENSG00000183706; Tissue enriched (testis).
DR neXtProt; NX_Q8N0Y3; -.
DR PharmGKB; PA32332; -.
DR VEuPathDB; HostDB:ENSG00000183706; -.
DR eggNOG; ENOG502SKDS; Eukaryota.
DR GeneTree; ENSGT00940000162873; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8N0Y3; -.
DR OMA; STCITHV; -.
DR OrthoDB; 1130067at2759; -.
DR PhylomeDB; Q8N0Y3; -.
DR TreeFam; TF338273; -.
DR PathwayCommons; Q8N0Y3; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 102723532; 0 hits in 3 CRISPR screens.
DR BioGRID-ORCS; 283694; 29 hits in 622 CRISPR screens.
DR GeneWiki; OR4N4; -.
DR Pharos; Q8N0Y3; Tdark.
DR PRO; PR:Q8N0Y3; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q8N0Y3; protein.
DR Bgee; ENSG00000183706; Expressed in left testis and 4 other tissues.
DR ExpressionAtlas; Q8N0Y3; baseline.
DR Genevisible; Q8N0Y3; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..316
FT /note="Olfactory receptor 4N4"
FT /id="PRO_0000150564"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 61
FT /note="L -> F (in dbSNP:rs535034)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_048034"
FT VARIANT 86
FT /note="L -> F (in dbSNP:rs2808136)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_048035"
FT VARIANT 239
FT /note="T -> M (in dbSNP:rs475947)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_048036"
FT VARIANT 274
FT /note="F -> L (in dbSNP:rs3817271)"
FT /id="VAR_048037"
SQ SEQUENCE 316 AA; 35724 MW; 826814BC3572C926 CRC64;
MKIANNTVVT EFILLGLTQS QDIQLLVFVL ILIFYLIILP GNFLIIFTIR SDPGLTAPLY
LFLGNLAFLD ASYSFIVAPR MLVDFLSEKK VISYRGCITQ LFFLHFLGGG EGLLLVVMAF
DRYIAICRPL HCSTVMNPRA CYAMMLALWL GGFVHSIIQV VLILRLPFCG PNQLDNFFCD
VRQVIKLACT DMFVVELLMV FNSGLMTLLC FLGLLASYAV ILCHVRRAAS EGKNKAMSTC
TTRVIIILLM FGPAIFIYMC PFRALPADKM VSLFHTVIFP LMNPMIYTLR NQEVKTSMKR
LLSRHVVCQV DFIIRN
