OR4N5_HUMAN
ID OR4N5_HUMAN Reviewed; 308 AA.
AC Q8IXE1; Q6IF11;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Olfactory receptor 4N5;
DE AltName: Full=Olfactory receptor OR14-33;
GN Name=OR4N5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4N5";
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DR EMBL; AB065890; BAC45262.1; -; Genomic_DNA.
DR EMBL; BK004451; DAA04849.1; -; Genomic_DNA.
DR CCDS; CCDS32031.1; -.
DR RefSeq; NP_001004724.1; NM_001004724.1.
DR AlphaFoldDB; Q8IXE1; -.
DR SMR; Q8IXE1; -.
DR BioGRID; 133564; 1.
DR IntAct; Q8IXE1; 1.
DR STRING; 9606.ENSP00000332110; -.
DR GlyGen; Q8IXE1; 1 site.
DR iPTMnet; Q8IXE1; -.
DR PhosphoSitePlus; Q8IXE1; -.
DR BioMuta; OR4N5; -.
DR DMDM; 37081339; -.
DR PaxDb; Q8IXE1; -.
DR PeptideAtlas; Q8IXE1; -.
DR PRIDE; Q8IXE1; -.
DR Antibodypedia; 70558; 21 antibodies from 14 providers.
DR DNASU; 390437; -.
DR Ensembl; ENST00000641086.1; ENSP00000493307.1; ENSG00000184394.3.
DR GeneID; 390437; -.
DR KEGG; hsa:390437; -.
DR MANE-Select; ENST00000641086.1; ENSP00000493307.1; NM_001004724.2; NP_001004724.1.
DR UCSC; uc010tla.2; human.
DR CTD; 390437; -.
DR GeneCards; OR4N5; -.
DR HGNC; HGNC:15358; OR4N5.
DR HPA; ENSG00000184394; Not detected.
DR neXtProt; NX_Q8IXE1; -.
DR PharmGKB; PA32333; -.
DR VEuPathDB; HostDB:ENSG00000184394; -.
DR eggNOG; ENOG502SKDS; Eukaryota.
DR GeneTree; ENSGT00940000162920; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8IXE1; -.
DR OMA; YAVILYH; -.
DR OrthoDB; 1130067at2759; -.
DR PhylomeDB; Q8IXE1; -.
DR TreeFam; TF338273; -.
DR PathwayCommons; Q8IXE1; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8IXE1; -.
DR BioGRID-ORCS; 390437; 2 hits in 665 CRISPR screens.
DR ChiTaRS; OR4N5; human.
DR GeneWiki; OR4N5; -.
DR GenomeRNAi; 390437; -.
DR Pharos; Q8IXE1; Tdark.
DR PRO; PR:Q8IXE1; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8IXE1; protein.
DR ExpressionAtlas; Q8IXE1; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..308
FT /note="Olfactory receptor 4N5"
FT /id="PRO_0000150565"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..308
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 191
FT /note="N -> D (in dbSNP:rs10131326)"
FT /id="VAR_024095"
FT VARIANT 234
FT /note="S -> T (in dbSNP:rs10140908)"
FT /id="VAR_034208"
FT VARIANT 260
FT /note="C -> R (in dbSNP:rs10134472)"
FT /id="VAR_034209"
FT VARIANT 290
FT /note="R -> H (in dbSNP:rs10141025)"
FT /id="VAR_053175"
SQ SEQUENCE 308 AA; 34696 MW; 4A123FBB723822BD CRC64;
METQNLTVVT EFILLGLTQS QDAQLLVFVL VLIFYLIILP GNFLIIFTIK SDPGLTAPLY
FFLGNLALLD ASYSFIVVPR MLVDFLSEKK VISYRSCITQ LFFLHFLGAG EMFLLVVMAF
DRYIAICRPL HYSTIMNPRA CYALSLVLWL GGFIHSIVQV ALILHLPFCG PNQLDNFFCD
VPQVIKLACT NTFVVELLMV SNSGLLSLLC FLGLLASYAV ILCRIREHSS EGKSKAISTC
TTHIIIIFLM FGPAIFIYTC PFQAFPADKV VSLFHTVIFP LMNPVIYTLR NQEVKASMRK
LLSQHMFC
