OR4Q3_HUMAN
ID OR4Q3_HUMAN Reviewed; 313 AA.
AC Q8NH05; Q6IEX4;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Olfactory receptor 4Q3;
DE AltName: Full=Olfactory receptor 4Q4;
DE AltName: Full=Olfactory receptor OR14-3;
GN Name=OR4Q3; Synonyms=C14orf13, OR4Q4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4Q3";
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DR EMBL; AB065609; BAC05836.1; -; Genomic_DNA.
DR EMBL; BK004488; DAA04886.1; -; Genomic_DNA.
DR CCDS; CCDS32020.1; -.
DR RefSeq; NP_751944.1; NM_172194.1.
DR AlphaFoldDB; Q8NH05; -.
DR SMR; Q8NH05; -.
DR BioGRID; 137666; 2.
DR STRING; 9606.ENSP00000330049; -.
DR GlyGen; Q8NH05; 1 site.
DR BioMuta; OR4Q3; -.
DR DMDM; 38372800; -.
DR PaxDb; Q8NH05; -.
DR PeptideAtlas; Q8NH05; -.
DR PRIDE; Q8NH05; -.
DR DNASU; 441669; -.
DR GeneID; 441669; -.
DR KEGG; hsa:441669; -.
DR UCSC; uc010tkt.2; human.
DR CTD; 441669; -.
DR GeneCards; OR4Q3; -.
DR HGNC; HGNC:15426; OR4Q3.
DR neXtProt; NX_Q8NH05; -.
DR PharmGKB; PA32340; -.
DR eggNOG; ENOG502QVQ8; Eukaryota.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NH05; -.
DR OrthoDB; 897665at2759; -.
DR PhylomeDB; Q8NH05; -.
DR TreeFam; TF337350; -.
DR PathwayCommons; Q8NH05; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 441669; 8 hits in 635 CRISPR screens.
DR GeneWiki; OR4Q3; -.
DR GenomeRNAi; 441669; -.
DR Pharos; Q8NH05; Tbio.
DR PRO; PR:Q8NH05; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NH05; protein.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 4Q3"
FT /id="PRO_0000150567"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 135
FT /note="T -> A (in dbSNP:rs17210864)"
FT /id="VAR_053176"
FT VARIANT 238
FT /note="F -> L (in dbSNP:rs12896533)"
FT /id="VAR_053177"
SQ SEQUENCE 313 AA; 35491 MW; 5990F692887115DD CRC64;
MKKEQDSNVT EFVLLGLSSS WELQLFLFLL FLFFYIAIVL GNLLIVVTVQ AHAHLLQSPM
YYFLGHLSFI DLCLSCVTVP KMLGDFLQQG KSISFSGCLA QIYFLHFLGA SEMFLLTVMA
YDRYVAICNP LRYLTVMNPQ LCLWLVLACW CGGFIHSIMQ VILVIQLPFC GPNELDNFYC
DVPQVIKLAC MDTYVVEVLV IANSGLLSLV CFLVLLFSYA IILITLRTHF CQGQNKVFST
CASHLTVVSL IFVPCVFIYL RPFCSFSVDK IFSLFYTVIT PMLNPLIYTL RNTDMKTAMK
KLRIKPCGIP LPC
