OR4S1_HUMAN
ID OR4S1_HUMAN Reviewed; 309 AA.
AC Q8NGB4; Q6IFB4;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 4S1;
DE AltName: Full=Olfactory receptor OR11-100;
GN Name=OR4S1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="https://genome.weizmann.ac.il/horde/card/index/symbol:OR4S1/term:OR4S1/type:keyword";
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DR EMBL; AB065908; BAC06123.1; -; Genomic_DNA.
DR EMBL; BK004348; DAA04746.1; -; Genomic_DNA.
DR CCDS; CCDS31488.1; -.
DR RefSeq; NP_001004725.1; NM_001004725.1.
DR AlphaFoldDB; Q8NGB4; -.
DR SMR; Q8NGB4; -.
DR STRING; 9606.ENSP00000321447; -.
DR GlyGen; Q8NGB4; 1 site.
DR BioMuta; OR4S1; -.
DR DMDM; 38372656; -.
DR jPOST; Q8NGB4; -.
DR PaxDb; Q8NGB4; -.
DR PeptideAtlas; Q8NGB4; -.
DR PRIDE; Q8NGB4; -.
DR Antibodypedia; 56836; 68 antibodies from 16 providers.
DR DNASU; 256148; -.
DR Ensembl; ENST00000319988.1; ENSP00000321447.1; ENSG00000176555.1.
DR GeneID; 256148; -.
DR KEGG; hsa:256148; -.
DR MANE-Select; ENST00000319988.1; ENSP00000321447.1; NM_001004725.1; NP_001004725.1.
DR UCSC; uc010rhu.2; human.
DR CTD; 256148; -.
DR GeneCards; OR4S1; -.
DR HGNC; HGNC:14705; OR4S1.
DR HPA; ENSG00000176555; Not detected.
DR neXtProt; NX_Q8NGB4; -.
DR OpenTargets; ENSG00000176555; -.
DR PharmGKB; PA32344; -.
DR VEuPathDB; HostDB:ENSG00000176555; -.
DR eggNOG; ENOG502RCGN; Eukaryota.
DR GeneTree; ENSGT00940000164171; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGB4; -.
DR OMA; MQHACFV; -.
DR OrthoDB; 1082090at2759; -.
DR PhylomeDB; Q8NGB4; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; Q8NGB4; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 256148; 78 hits in 666 CRISPR screens.
DR GeneWiki; OR4S1; -.
DR GenomeRNAi; 256148; -.
DR Pharos; Q8NGB4; Tdark.
DR PRO; PR:Q8NGB4; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGB4; protein.
DR ExpressionAtlas; Q8NGB4; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 4S1"
FT /id="PRO_0000150568"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..287
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 309 AA; 34800 MW; C5FD2BC0023CEF06 CRC64;
MGAKNNVTEF VLFGLFESRE MQHTCFVVFF LFHVLTVLGN LLVIITINAR KTLKSPMYFF
LSQLSFADIC YPSTTIPKMI ADTFVEHKII SFNGCMTQLF SAHFFGGTEI FLLTAMAYDR
YVAICRPLHY TAIMDCRKCG LLAGASWLAG FLHSILQTLL TVQLPFCGPN EIDNFFCDVH
PLLKLACADT YMVGLIVVAN SGMISLASFF ILIISYVIIL LNLRSQSSED RRKAVSTCGS
HVITVLLVLM PPMFMYIRPS TTLAADKLII LFNIVMPPLL NPLIYTLRNN DVKNAMRKLF
RVKRSLGEK
