ID   OR4S2_HUMAN             Reviewed;         311 AA.
AC   Q8NH73; Q6IF72;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   03-AUG-2022, entry version 151.
DE   RecName: Full=Olfactory receptor 4S2;
DE   AltName: Full=Olfactory receptor OR11-137;
GN   Name=OR4S2; Synonyms=OR4S2P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4S2";
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DR   EMBL; AB065516; BAC05764.1; -; Genomic_DNA.
DR   EMBL; AP006437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK004390; DAA04788.1; -; Genomic_DNA.
DR   CCDS; CCDS31505.1; -.
DR   RefSeq; NP_001004059.2; NM_001004059.2.
DR   AlphaFoldDB; Q8NH73; -.
DR   SMR; Q8NH73; -.
DR   BioGRID; 128532; 3.
DR   STRING; 9606.ENSP00000310337; -.
DR   GlyGen; Q8NH73; 1 site.
DR   iPTMnet; Q8NH73; -.
DR   PhosphoSitePlus; Q8NH73; -.
DR   BioMuta; OR4S2; -.
DR   DMDM; 296439253; -.
DR   PaxDb; Q8NH73; -.
DR   PeptideAtlas; Q8NH73; -.
DR   PRIDE; Q8NH73; -.
DR   Antibodypedia; 66621; 71 antibodies from 18 providers.
DR   DNASU; 219431; -.
DR   Ensembl; ENST00000641692.1; ENSP00000493389.1; ENSG00000174982.4.
DR   GeneID; 219431; -.
DR   KEGG; hsa:219431; -.
DR   MANE-Select; ENST00000641692.1; ENSP00000493389.1; NM_001004059.3; NP_001004059.2.
DR   UCSC; uc001nhs.1; human.
DR   CTD; 219431; -.
DR   GeneCards; OR4S2; -.
DR   HGNC; HGNC:15183; OR4S2.
DR   HPA; ENSG00000174982; Not detected.
DR   neXtProt; NX_Q8NH73; -.
DR   OpenTargets; ENSG00000174982; -.
DR   PharmGKB; PA32345; -.
DR   VEuPathDB; HostDB:ENSG00000174982; -.
DR   eggNOG; ENOG502RCGN; Eukaryota.
DR   GeneTree; ENSGT00940000161123; -.
DR   HOGENOM; CLU_012526_8_1_1; -.
DR   InParanoid; Q8NH73; -.
DR   OMA; IEKVCFV; -.
DR   OrthoDB; 1082090at2759; -.
DR   PhylomeDB; Q8NH73; -.
DR   TreeFam; TF336512; -.
DR   PathwayCommons; Q8NH73; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 219431; 9 hits in 638 CRISPR screens.
DR   GeneWiki; OR4S2; -.
DR   GenomeRNAi; 219431; -.
DR   Pharos; Q8NH73; Tdark.
DR   PRO; PR:Q8NH73; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NH73; protein.
DR   ExpressionAtlas; Q8NH73; differential.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..311
FT                   /note="Olfactory receptor 4S2"
FT                   /id="PRO_0000150569"
FT   TOPO_DOM        1..23
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..47
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..77
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..137
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..156
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        157..193
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..233
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..256
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..267
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..287
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        288..311
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        95..187
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         72
FT                   /note="S -> T (in dbSNP:rs17146960)"
FT                   /id="VAR_057547"
FT   VARIANT         195
FT                   /note="V -> G (in dbSNP:rs7949664)"
FT                   /id="VAR_057548"
FT   CONFLICT        100
FT                   /note="F -> L (in Ref. 1; BAC05764)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   311 AA;  35172 MW;  DAA0084EA91026D1 CRC64;
     MEKINNVTEF IFWGLSQSPE IEKVCFVVFS FFYIIILLGN LLIMLTVCLS NLFKSPMYFF
     LSFLSFVDIC YSSVTAPKMI VDLLAKDKTI SYVGCMLQLF GVHFFGCTEI FILTVMAYDR
     YVAICKPLHY MTIMNRETCN KMLLGTWVGG FLHSIIQVAL VVQLPFCGPN EIDHYFCDVH
     PVLKLACTET YIVGVVVTAN SGTIALGSFV ILLISYSIIL VSLRKQSAEG RRKALSTCGS
     HIAMVVIFFG PCTFMYMRPD TTFSEDKMVA VFYTIITPML NPLIYTLRNA EVKNAMKKLW
     GRNVFLEAKG K