OR4X1_HUMAN
ID OR4X1_HUMAN Reviewed; 305 AA.
AC Q8NH49; Q6IF74;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Olfactory receptor 4X1;
DE AltName: Full=Olfactory receptor OR11-104;
GN Name=OR4X1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4X1";
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DR EMBL; AB065544; BAC05789.1; -; Genomic_DNA.
DR EMBL; BK004388; DAA04786.1; -; Genomic_DNA.
DR CCDS; CCDS31487.1; -.
DR RefSeq; NP_001004726.1; NM_001004726.1.
DR AlphaFoldDB; Q8NH49; -.
DR SMR; Q8NH49; -.
DR BioGRID; 133405; 1.
DR STRING; 9606.ENSP00000321506; -.
DR GlyGen; Q8NH49; 2 sites.
DR BioMuta; OR4X1; -.
DR DMDM; 38372808; -.
DR MassIVE; Q8NH49; -.
DR PaxDb; Q8NH49; -.
DR PeptideAtlas; Q8NH49; -.
DR PRIDE; Q8NH49; -.
DR Antibodypedia; 56835; 82 antibodies from 19 providers.
DR DNASU; 390113; -.
DR Ensembl; ENST00000320048.1; ENSP00000321506.1; ENSG00000176567.1.
DR GeneID; 390113; -.
DR KEGG; hsa:390113; -.
DR MANE-Select; ENST00000320048.1; ENSP00000321506.1; NM_001004726.1; NP_001004726.1.
DR UCSC; uc010rht.2; human.
DR CTD; 390113; -.
DR DisGeNET; 390113; -.
DR GeneCards; OR4X1; -.
DR HGNC; HGNC:14854; OR4X1.
DR HPA; ENSG00000176567; Not detected.
DR neXtProt; NX_Q8NH49; -.
DR OpenTargets; ENSG00000176567; -.
DR PharmGKB; PA32350; -.
DR VEuPathDB; HostDB:ENSG00000176567; -.
DR eggNOG; ENOG502T9N0; Eukaryota.
DR GeneTree; ENSGT00940000164050; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NH49; -.
DR OMA; MRPCVTL; -.
DR OrthoDB; 1082090at2759; -.
DR PhylomeDB; Q8NH49; -.
DR TreeFam; TF337350; -.
DR PathwayCommons; Q8NH49; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390113; 2 hits in 669 CRISPR screens.
DR ChiTaRS; OR4X1; human.
DR GeneWiki; OR4X1; -.
DR GenomeRNAi; 390113; -.
DR Pharos; Q8NH49; Tdark.
DR PRO; PR:Q8NH49; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH49; protein.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..305
FT /note="Olfactory receptor 4X1"
FT /id="PRO_0000150570"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..287
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..305
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 144
FT /note="R -> G (in dbSNP:rs1503193)"
FT /id="VAR_053178"
FT VARIANT 165
FT /note="P -> L (in dbSNP:rs16905753)"
FT /id="VAR_034210"
FT VARIANT 196
FT /note="L -> Q (in dbSNP:rs12798361)"
FT /id="VAR_053179"
FT VARIANT 246
FT /note="D -> N (in dbSNP:rs17199104)"
FT /id="VAR_034211"
FT VARIANT 282
FT /note="P -> S (in dbSNP:rs10838852)"
FT /id="VAR_034212"
SQ SEQUENCE 305 AA; 34222 MW; 730C81DE29E63D92 CRC64;
MVATNNVTEI IFVGFSQNWS EQRVISVMFL LMYTAVVLGN GLIVVTILAS KVLTSPMYFF
LSYLSFVEIC YCSVMAPKLI FDSFIKRKVI SLKGCLTQMF SLHFFGGTEA FLLMVMAYDR
YVAICKPLHY MAIMNQRMCG LLVRIAWGGG LLHSVGQTFL IFQLPFCGPN IMDHYFCDVH
PVLELACADT FFISLLIITN GGSISVVSFF VLMASYLIIL HFLRSHNLEG QHKALSTCAS
HVTVVDLFFI PCSLVYIRPC VTLPADKIVA VFYTVVTPLL NPVIYSFRNA EVKNAMRRFI
GGKVI
