OR4X2_HUMAN
ID OR4X2_HUMAN Reviewed; 303 AA.
AC Q8NGF9; B2RNK3; Q6IF73; Q96R63;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Olfactory receptor 4X2;
DE AltName: Full=Olfactory receptor OR11-105;
GN Name=OR4X2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-272.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN [7]
RP POLYMORPHISM.
RX PubMed=17973576; DOI=10.1371/journal.pbio.0050284;
RA Menashe I., Abaffy T., Hasin Y., Goshen S., Yahalom V., Luetje C.W.,
RA Lancet D.;
RT "Genetic elucidation of human hyperosmia to isovaleric acid.";
RL PLoS Biol. 5:2462-2468(2007).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- POLYMORPHISM: A stop codon in the gene coding for this protein at
CC position Tyr-27 is responsible for functional diversity thus producing
CC a pseudogene.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4X2";
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DR EMBL; AB065847; BAC06065.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW67871.1; -; Genomic_DNA.
DR EMBL; BC136935; AAI36936.1; -; mRNA.
DR EMBL; BC136936; AAI36937.1; -; mRNA.
DR EMBL; AF399580; AAK95065.1; -; Genomic_DNA.
DR EMBL; BK004389; DAA04787.1; -; Genomic_DNA.
DR RefSeq; NP_001004727.1; NM_001004727.1.
DR AlphaFoldDB; Q8NGF9; -.
DR SMR; Q8NGF9; -.
DR BioGRID; 125659; 20.
DR STRING; 9606.ENSP00000485191; -.
DR iPTMnet; Q8NGF9; -.
DR PhosphoSitePlus; Q8NGF9; -.
DR BioMuta; OR4X2; -.
DR DMDM; 38372683; -.
DR MassIVE; Q8NGF9; -.
DR PaxDb; Q8NGF9; -.
DR PeptideAtlas; Q8NGF9; -.
DR PRIDE; Q8NGF9; -.
DR Antibodypedia; 80237; 75 antibodies from 18 providers.
DR DNASU; 119764; -.
DR Ensembl; ENST00000624868.2; ENSP00000485431.1; ENSG00000172208.7.
DR GeneID; 119764; -.
DR KEGG; hsa:119764; -.
DR MANE-Select; ENST00000624868.2; ENSP00000485431.1; NM_001004727.1; NP_001004727.1.
DR UCSC; uc001ngs.1; human.
DR CTD; 119764; -.
DR GeneCards; OR4X2; -.
DR HGNC; HGNC:15184; OR4X2.
DR HPA; ENSG00000172208; Not detected.
DR neXtProt; NX_Q8NGF9; -.
DR PharmGKB; PA32351; -.
DR VEuPathDB; HostDB:ENSG00000172208; -.
DR eggNOG; ENOG502SKRP; Eukaryota.
DR GeneTree; ENSGT00940000158345; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGF9; -.
DR OMA; RLWIRTM; -.
DR OrthoDB; 1082090at2759; -.
DR PhylomeDB; Q8NGF9; -.
DR TreeFam; TF337350; -.
DR PathwayCommons; Q8NGF9; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 119764; 8 hits in 668 CRISPR screens.
DR GeneWiki; OR4X2; -.
DR GenomeRNAi; 119764; -.
DR Pharos; Q8NGF9; Tdark.
DR PRO; PR:Q8NGF9; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGF9; protein.
DR Bgee; ENSG00000172208; Expressed in granulocyte.
DR ExpressionAtlas; Q8NGF9; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..303
FT /note="Olfactory receptor 4X2"
FT /id="PRO_0000150571"
FT TOPO_DOM 1..17
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..41
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 42..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..71
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..92
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..112
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..150
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 151..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..211
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..227
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..250
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..261
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..281
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 282..303
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 89..181
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 303 AA; 34289 MW; 4C4C934B7C6FBFCF CRC64;
MTEFIFLVLS PNQEVQRVCF VIFLFLYTAI VLGNFLIVLT VMTSRSLGSP MYFFLSYLSF
MEICYSSATA PKLISDLLAE RKVISWWGCM AQLFFLHFFG GTEIFLLTVM AYDHYVAICK
PLSYTTIMNW QVCTVLVGIA WVGGFMHSFA QILLIFHLLF CGPNVINHYF CDLVPLLKLA
CSDTFLIGLL IVANGGTLSV ISFGVLLASY MVILLHLRTW SSEGWCKALS TCGSHFAVVI
LFFGPCVFNS LRPSTTLPID KMVAVFYTVI TAILNPVIYS LRNAEMRKAM KRLWIRTLRL
NEK
