OR56A_DROME
ID OR56A_DROME Reviewed; 419 AA.
AC Q9V8Y7;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Odorant receptor 56a;
GN Name=Or56a; ORFNames=CG12501;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=10943836; DOI=10.1016/s0092-8674(00)00021-0;
RA Vosshall L.B., Wong A.M., Axel R.;
RT "An olfactory sensory map in the fly brain.";
RL Cell 102:147-159(2000).
RN [4]
RP TISSUE SPECIFICITY, AND FUNCTION.
RX PubMed=23217715; DOI=10.1016/j.cell.2012.09.046;
RA Stensmyr M.C., Dweck H.K., Farhan A., Ibba I., Strutz A., Mukunda L.,
RA Linz J., Grabe V., Steck K., Lavista-Llanos S., Wicher D., Sachse S.,
RA Knaden M., Becher P.G., Seki Y., Hansson B.S.;
RT "A conserved dedicated olfactory circuit for detecting harmful microbes in
RT Drosophila.";
RL Cell 151:1345-1357(2012).
CC -!- FUNCTION: Odorant receptor which mediates acceptance or avoidance
CC behavior, depending on its substrates. The odorant receptor repertoire
CC encodes a large collection of odor stimuli that vary widely in
CC identity, intensity, and duration. May form a complex with Orco to form
CC odorant-sensing units, providing sensitive and prolonged odorant
CC signaling and calcium permeability. Specific receptor for geosmin, a
CC microbial odorant that constitutes an ecologically relevant stimulus
CC that alerts flies to the presence of harmful microbes and induces
CC avoidance behavior. {ECO:0000269|PubMed:23217715}.
CC -!- SUBUNIT: Interacts with Orco. Complexes exist early in the endomembrane
CC system in olfactory sensory neurons (OSNs), coupling these complexes to
CC the conserved ciliary trafficking pathway (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in olfactory sensory neurons in the
CC antenna. {ECO:0000269|PubMed:10943836, ECO:0000269|PubMed:23217715}.
CC -!- MISCELLANEOUS: The atypical heteromeric and topological design of the
CC odorant receptors appears to be an insect-specific solution for odor
CC recognition, making the OR/Orco complex an attractive target for the
CC development of highly selective insect repellents to disrupt olfactory-
CC mediated host-seeking behaviors of insect disease vectors. Odor-evoked
CC OR currents are independent of known G-protein-coupled second messenger
CC pathways.
CC -!- SIMILARITY: Belongs to the insect chemoreceptor superfamily.
CC Heteromeric odorant receptor channel (TC 1.A.69) family. Or30a
CC subfamily. {ECO:0000305}.
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DR EMBL; AE013599; AAF57517.2; -; Genomic_DNA.
DR RefSeq; NP_523796.2; NM_079072.2.
DR AlphaFoldDB; Q9V8Y7; -.
DR SMR; Q9V8Y7; -.
DR BioGRID; 62925; 1.
DR DIP; DIP-20737N; -.
DR IntAct; Q9V8Y7; 3.
DR STRING; 7227.FBpp0085645; -.
DR TCDB; 1.A.69.1.3; the heteromeric odorant receptor channel (horc) family.
DR PaxDb; Q9V8Y7; -.
DR EnsemblMetazoa; FBtr0086344; FBpp0085645; FBgn0034473.
DR GeneID; 37269; -.
DR KEGG; dme:Dmel_CG12501; -.
DR CTD; 37269; -.
DR FlyBase; FBgn0034473; Or56a.
DR VEuPathDB; VectorBase:FBgn0034473; -.
DR eggNOG; ENOG502T0RU; Eukaryota.
DR HOGENOM; CLU_716252_0_0_1; -.
DR InParanoid; Q9V8Y7; -.
DR OMA; WYGYVAS; -.
DR OrthoDB; 1109412at2759; -.
DR PhylomeDB; Q9V8Y7; -.
DR BioGRID-ORCS; 37269; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 37269; -.
DR PRO; PR:Q9V8Y7; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034473; Expressed in antenna and 6 other tissues.
DR Genevisible; Q9V8Y7; DM.
DR GO; GO:0032590; C:dendrite membrane; ISS:FlyBase.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR GO; GO:0004984; F:olfactory receptor activity; IDA:FlyBase.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IDA:FlyBase.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR InterPro; IPR004117; 7tm6_olfct_rcpt.
DR PANTHER; PTHR21137; PTHR21137; 1.
DR Pfam; PF02949; 7tm_6; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Olfaction; Receptor; Reference proteome;
KW Sensory transduction; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..419
FT /note="Odorant receptor 56a"
FT /id="PRO_0000174254"
FT TOPO_DOM 1..41
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..76
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..292
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 314..323
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 345..389
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 390..410
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 411..419
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 419 AA; 48920 MW; F5F82545D2560040 CRC64;
MFKVKDLLLS PTTFEDPIFG THLRYFQWYG YVASKDQNRP LLSLIRCTIL TASIWLSCAL
MLARVFRGYE NLNDGATSYA TAVQYFAVSI AMFNAYVQRD KVISLLRVAH SDIQNLMHEA
DNREMELLVA TQAYTRTITL LIWIPSVIAG LMAYSDCIYR SLFLPKSVFN VPAVRRGEEH
PILLFQLFPF GELCDNFVVG YLGPWYALGL GITAIPLWHT FITCLMKYVN LKLQILNKRV
EEMDITRLNS KLVIGRLTAS ELTFWQMQLF KEFVKEQLRI RKFVQELQYL ICVPVMADFI
IFSVLICFLF FALTVGVPSK MDYFFMFIYL FVMAGILWIY HWHATLIVEC HDELSLAYFS
CGWYNFEMPL QKMLVFMMMH AQRPMKMRAL LVDLNLRTFI DIGRGAYSYF NLLRSSHLY
