OR5A1_HUMAN
ID OR5A1_HUMAN Reviewed; 315 AA.
AC Q8NGJ0; B9EH58; Q6IFF2; Q96RB1;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Olfactory receptor 5A1;
DE AltName: Full=OST181;
DE AltName: Full=Olfactory receptor OR11-249;
GN Name=OR5A1; Synonyms=OR5A1P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-183.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-286.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5A1";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065804; BAC06023.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW73844.1; -; Genomic_DNA.
DR EMBL; BC137060; AAI37061.1; -; mRNA.
DR EMBL; BC137061; AAI37062.1; -; mRNA.
DR EMBL; AF399528; AAK95013.1; -; Genomic_DNA.
DR EMBL; BK004310; DAA04708.1; -; Genomic_DNA.
DR CCDS; CCDS31561.1; -.
DR RefSeq; NP_001004728.1; NM_001004728.1.
DR AlphaFoldDB; Q8NGJ0; -.
DR SMR; Q8NGJ0; -.
DR IntAct; Q8NGJ0; 1.
DR STRING; 9606.ENSP00000303096; -.
DR GlyGen; Q8NGJ0; 1 site.
DR iPTMnet; Q8NGJ0; -.
DR PhosphoSitePlus; Q8NGJ0; -.
DR BioMuta; OR5A1; -.
DR DMDM; 38372702; -.
DR MassIVE; Q8NGJ0; -.
DR PaxDb; Q8NGJ0; -.
DR PeptideAtlas; Q8NGJ0; -.
DR PRIDE; Q8NGJ0; -.
DR ProteomicsDB; 73526; -.
DR Antibodypedia; 58822; 43 antibodies from 16 providers.
DR DNASU; 219982; -.
DR Ensembl; ENST00000641045.1; ENSP00000493195.1; ENSG00000172320.4.
DR GeneID; 219982; -.
DR KEGG; hsa:219982; -.
DR MANE-Select; ENST00000641045.1; ENSP00000493195.1; NM_001004728.2; NP_001004728.1.
DR UCSC; uc001nnx.2; human.
DR CTD; 219982; -.
DR GeneCards; OR5A1; -.
DR HGNC; HGNC:8319; OR5A1.
DR HPA; ENSG00000172320; Tissue enhanced (brain).
DR neXtProt; NX_Q8NGJ0; -.
DR PharmGKB; PA32454; -.
DR VEuPathDB; HostDB:ENSG00000172320; -.
DR eggNOG; ENOG502SMFV; Eukaryota.
DR GeneTree; ENSGT01050000244931; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGJ0; -.
DR OMA; MLTDFFQ; -.
DR OrthoDB; 921007at2759; -.
DR PhylomeDB; Q8NGJ0; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NGJ0; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGJ0; -.
DR BioGRID-ORCS; 219982; 22 hits in 669 CRISPR screens.
DR GeneWiki; OR5A1; -.
DR GenomeRNAi; 219982; -.
DR Pharos; Q8NGJ0; Tdark.
DR PRO; PR:Q8NGJ0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGJ0; protein.
DR Bgee; ENSG00000172320; Expressed in anatomical system and 5 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..315
FT /note="Olfactory receptor 5A1"
FT /id="PRO_0000150572"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..82
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..123
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..222
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..262
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..315
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 100..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 52
FT /note="I -> V (in dbSNP:rs17153732)"
FT /id="VAR_034213"
FT VARIANT 183
FT /note="D -> N (in dbSNP:rs6591536)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_024096"
SQ SEQUENCE 315 AA; 35152 MW; EF096B7068244DC5 CRC64;
MSITKAWNSS SVTMFILLGF TDHPELQALL FVTFLGIYLT TLAWNLALIF LIRGDTHLHT
PMYFFLSNLS FIDICYSSAV APNMLTDFFW EQKTISFVGC AAQFFFFVGM GLSECLLLTA
MAYDRYAAIS SPLLYPTIMT QGLCTRMVVG AYVGGFLSSL IQASSIFRLH FCGPNIINHF
FCDLPPVLAL SCSDTFLSQV VNFLVVVTVG GTSFLQLLIS YGYIVSAVLK IPSAEGRWKA
CNTCASHLMV VTLLFGTALF VYLRPSSSYL LGRDKVVSVF YSLVIPMLNP LIYSLRNKEI
KDALWKVLER KKVFS
