OR5A2_HUMAN
ID OR5A2_HUMAN Reviewed; 324 AA.
AC Q8NGI9; B9EH21; Q6IFF4; Q96RB0;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Olfactory receptor 5A2;
DE AltName: Full=Olfactory receptor OR11-248;
GN Name=OR5A2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-285.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5A2";
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DR EMBL; AB065805; BAC06024.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW73843.1; -; Genomic_DNA.
DR EMBL; BC136991; AAI36992.1; -; mRNA.
DR EMBL; AF399529; AAK95014.1; -; Genomic_DNA.
DR EMBL; BK004308; DAA04706.1; -; Genomic_DNA.
DR CCDS; CCDS31560.1; -.
DR RefSeq; NP_001001954.1; NM_001001954.1.
DR AlphaFoldDB; Q8NGI9; -.
DR SMR; Q8NGI9; -.
DR BioGRID; 128609; 3.
DR IntAct; Q8NGI9; 4.
DR STRING; 9606.ENSP00000303834; -.
DR GlyGen; Q8NGI9; 1 site.
DR iPTMnet; Q8NGI9; -.
DR PhosphoSitePlus; Q8NGI9; -.
DR BioMuta; OR5A2; -.
DR DMDM; 37081361; -.
DR MaxQB; Q8NGI9; -.
DR PaxDb; Q8NGI9; -.
DR PeptideAtlas; Q8NGI9; -.
DR PRIDE; Q8NGI9; -.
DR ProteomicsDB; 73525; -.
DR Antibodypedia; 58820; 53 antibodies from 17 providers.
DR DNASU; 219981; -.
DR Ensembl; ENST00000302040.6; ENSP00000303834.4; ENSG00000172324.6.
DR Ensembl; ENST00000641361.1; ENSP00000493065.1; ENSG00000172324.6.
DR Ensembl; ENST00000641673.1; ENSP00000492975.1; ENSG00000172324.6.
DR GeneID; 219981; -.
DR KEGG; hsa:219981; -.
DR MANE-Select; ENST00000302040.6; ENSP00000303834.4; NM_001001954.2; NP_001001954.1.
DR UCSC; uc010rkt.3; human.
DR CTD; 219981; -.
DR DisGeNET; 219981; -.
DR GeneCards; OR5A2; -.
DR HGNC; HGNC:15249; OR5A2.
DR HPA; ENSG00000172324; Tissue enhanced (brain).
DR neXtProt; NX_Q8NGI9; -.
DR OpenTargets; ENSG00000172324; -.
DR PharmGKB; PA32455; -.
DR VEuPathDB; HostDB:ENSG00000172324; -.
DR eggNOG; ENOG502SMFV; Eukaryota.
DR GeneTree; ENSGT01050000244931; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGI9; -.
DR OMA; VQYFVFC; -.
DR OrthoDB; 946619at2759; -.
DR PhylomeDB; Q8NGI9; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NGI9; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGI9; -.
DR BioGRID-ORCS; 219981; 16 hits in 673 CRISPR screens.
DR GeneWiki; OR5A2; -.
DR GenomeRNAi; 219981; -.
DR Pharos; Q8NGI9; Tdark.
DR PRO; PR:Q8NGI9; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGI9; protein.
DR ExpressionAtlas; Q8NGI9; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..324
FT /note="Olfactory receptor 5A2"
FT /id="PRO_0000150573"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..324
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 103
FT /note="F -> L (in dbSNP:rs17153691)"
FT /id="VAR_048045"
FT VARIANT 172
FT /note="P -> L (in dbSNP:rs1453547)"
FT /id="VAR_024097"
SQ SEQUENCE 324 AA; 36016 MW; 2801C8878490C486 CRC64;
MAVGRNNTIV TKFILLGLSD HPQMKIFLFM LFLGLYLLTL AWNLSLIALI KMDSHLHMPM
YFFLSNLSFL DICYVSSTAP KMLSDIITEQ KTISFVGCAT QYFVFCGMGL TECFLLAAMA
YDRYAAICNP LLYTVLISHT LCLKMVVGAY VGGFLSSFIE TYSVYQHDFC GPYMINHFFC
DLPPVLALSC SDTFTSEVVT FIVSVVVGIV SVLVVLISYG YIVAAVVKIS SATGRTKAFS
TCASHLTAVT LFYGSGFFMY MRPSSSYSLN RDKVVSIFYA LVIPVVNPII YSFRNKEIKN
AMRKAMERDP GISHGGPFIF MTLG
