OR5B2_HUMAN
ID OR5B2_HUMAN Reviewed; 309 AA.
AC Q96R09; B2RNJ6; B9EGY7; Q6IEV7; Q8NGF5;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2003, sequence version 3.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Olfactory receptor 5B2;
DE AltName: Full=OST073;
DE AltName: Full=Olfactory receptor OR11-240;
GN Name=OR5B2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-200.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281, AND VARIANT THR-200.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5B2";
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DR EMBL; AB065852; BAC06070.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW73805.1; -; Genomic_DNA.
DR EMBL; BC136922; AAI36923.1; -; mRNA.
DR EMBL; BC136923; AAI36924.1; -; mRNA.
DR EMBL; AF399636; AAK95121.1; -; Genomic_DNA.
DR EMBL; BK004505; DAA04903.1; -; Genomic_DNA.
DR CCDS; CCDS31550.1; -.
DR RefSeq; NP_001005566.1; NM_001005566.2.
DR AlphaFoldDB; Q96R09; -.
DR SMR; Q96R09; -.
DR BioGRID; 133436; 1.
DR STRING; 9606.ENSP00000303076; -.
DR GlyGen; Q96R09; 1 site.
DR BioMuta; OR5B2; -.
DR DMDM; 38372840; -.
DR PaxDb; Q96R09; -.
DR PRIDE; Q96R09; -.
DR Antibodypedia; 77804; 4 antibodies from 4 providers.
DR DNASU; 390190; -.
DR Ensembl; ENST00000302581.2; ENSP00000303076.2; ENSG00000172365.4.
DR Ensembl; ENST00000641342.2; ENSP00000493419.1; ENSG00000172365.4.
DR GeneID; 390190; -.
DR KEGG; hsa:390190; -.
DR MANE-Select; ENST00000641342.2; ENSP00000493419.1; NM_001005566.3; NP_001005566.1.
DR UCSC; uc010rkg.2; human.
DR CTD; 390190; -.
DR GeneCards; OR5B2; -.
DR HGNC; HGNC:8323; OR5B2.
DR HPA; ENSG00000172365; Not detected.
DR neXtProt; NX_Q96R09; -.
DR PharmGKB; PA32490; -.
DR VEuPathDB; HostDB:ENSG00000172365; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT01040000240414; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q96R09; -.
DR OMA; CKSNTVH; -.
DR OrthoDB; 979582at2759; -.
DR PhylomeDB; Q96R09; -.
DR TreeFam; TF352754; -.
DR PathwayCommons; Q96R09; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390190; 8 hits in 663 CRISPR screens.
DR GeneWiki; OR5B2; -.
DR GenomeRNAi; 390190; -.
DR Pharos; Q96R09; Tdark.
DR PRO; PR:Q96R09; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q96R09; protein.
DR Bgee; ENSG00000172365; Expressed in descending thoracic aorta and 5 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 5B2"
FT /id="PRO_0000150585"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 200
FT /note="M -> T (in dbSNP:rs4298923)"
FT /evidence="ECO:0000269|PubMed:12213199,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_053181"
FT VARIANT 208
FT /note="V -> A (in dbSNP:rs10466659)"
FT /id="VAR_053182"
SQ SEQUENCE 309 AA; 34568 MW; A425E7A2DAC0D96C CRC64;
MENCTEVTKF ILLGLTSVPE LQIPLFILFT FIYLLTLCGN LGMMLLILMD SCLHTPMYFF
LSNLSLVDFG YSSAVTPKVM AGFLRGDKVI SYNACAVQMF FFVALATVEN YLLASMAYDR
YAAVCKPLHY TTTMTASVGA CLALGSYVCG FLNASFHIGG IFSLSFCKSN LVHHFFCDVP
AVMALSCSDK HTSEVILVFM SSFNIFFVLL VIFISYLFIF ITILKMHSAK GHQKALSTCA
SHFTAVSVFY GTVIFIYLQP SSSHSMDTDK MASVFYAMII PMLNPVVYSL RNREVQNAFK
KVLRRQKFL
