OR5B3_HUMAN
ID OR5B3_HUMAN Reviewed; 314 AA.
AC Q8NH48; Q6IEV6;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Olfactory receptor 5B3;
DE AltName: Full=Olfactory receptor 5B13;
DE AltName: Full=Olfactory receptor OR11-239;
GN Name=OR5B3; Synonyms=OR5B13;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5B3";
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DR EMBL; AB065545; BAC05790.1; -; Genomic_DNA.
DR EMBL; BK004506; DAA04904.1; -; Genomic_DNA.
DR CCDS; CCDS31549.1; -.
DR RefSeq; NP_001005469.1; NM_001005469.1.
DR AlphaFoldDB; Q8NH48; -.
DR SMR; Q8NH48; -.
DR BioGRID; 137615; 1.
DR IntAct; Q8NH48; 1.
DR STRING; 9606.ENSP00000308270; -.
DR GlyGen; Q8NH48; 3 sites.
DR iPTMnet; Q8NH48; -.
DR PhosphoSitePlus; Q8NH48; -.
DR BioMuta; OR5B3; -.
DR DMDM; 38372807; -.
DR MassIVE; Q8NH48; -.
DR PaxDb; Q8NH48; -.
DR PRIDE; Q8NH48; -.
DR Antibodypedia; 58768; 41 antibodies from 15 providers.
DR DNASU; 441608; -.
DR Ensembl; ENST00000641865.1; ENSP00000493217.1; ENSG00000172769.4.
DR GeneID; 441608; -.
DR KEGG; hsa:441608; -.
DR MANE-Select; ENST00000641865.1; ENSP00000493217.1; NM_001005469.2; NP_001005469.1.
DR UCSC; uc010rkf.3; human.
DR CTD; 441608; -.
DR GeneCards; OR5B3; -.
DR HGNC; HGNC:8324; OR5B3.
DR HPA; ENSG00000172769; Not detected.
DR neXtProt; NX_Q8NH48; -.
DR PharmGKB; PA32491; -.
DR VEuPathDB; HostDB:ENSG00000172769; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT01040000240414; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NH48; -.
DR OMA; QMYIFVA; -.
DR OrthoDB; 979582at2759; -.
DR PhylomeDB; Q8NH48; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NH48; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NH48; -.
DR BioGRID-ORCS; 441608; 16 hits in 607 CRISPR screens.
DR GeneWiki; OR5B3; -.
DR GenomeRNAi; 441608; -.
DR Pharos; Q8NH48; Tdark.
DR PRO; PR:Q8NH48; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH48; protein.
DR ExpressionAtlas; Q8NH48; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 5B3"
FT /id="PRO_0000150586"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 17
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 153
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 30
FT /note="P -> L (in dbSNP:rs17152661)"
FT /id="VAR_053183"
FT VARIANT 35
FT /note="I -> F (in dbSNP:rs17152659)"
FT /id="VAR_053184"
FT VARIANT 49
FT /note="W -> R (in dbSNP:rs11229413)"
FT /id="VAR_053185"
FT VARIANT 170
FT /note="N -> S (in dbSNP:rs12280114)"
FT /id="VAR_053186"
FT VARIANT 181
FT /note="A -> T (in dbSNP:rs11229411)"
FT /id="VAR_053187"
FT VARIANT 198
FT /note="I -> V (in dbSNP:rs11229410)"
FT /id="VAR_053188"
FT VARIANT 247
FT /note="G -> A (in dbSNP:rs11229409)"
FT /id="VAR_053189"
FT VARIANT 296
FT /note="K -> R (in dbSNP:rs12279895)"
FT /id="VAR_053190"
SQ SEQUENCE 314 AA; 35258 MW; 4E856ECC1F1154CF CRC64;
MENKTEVTQF ILLGLTNDSE LQVPLFITFP FIYIITLVGN LGIIVLIFWD SCLHNPMYFF
LSNLSLVDFC YSSAVTPIVM AGFLIEDKVI SYNACAAQMY IFVAFATVEN YLLASMAYDR
YAAVCKPLHY TTTMTTTVCA RLAIGSYLCG FLNASIHTGD TFSLSFCKSN EVHHFFCDIP
AVMVLSCSDR HISELVLIYV VSFNIFIALL VILISYTFIF ITILKMHSAS VYQKPLSTCA
SHFIAVGIFY GTIIFMYLQP SSSHSMDTDK MAPVFYTMVI PMLNPLVYSL RNKEVKSAFK
KVVEKAKLSV GWSV
