OR5BC_HUMAN
ID OR5BC_HUMAN Reviewed; 314 AA.
AC Q96R08; B2RNL2; Q6IEV5;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2002, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Olfactory receptor 5B12;
DE AltName: Full=Olfactory receptor 5B16;
DE AltName: Full=Olfactory receptor OR11-241;
GN Name=OR5B12; Synonyms=OR5B12P, OR5B16;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-141.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-141.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5B12";
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DR EMBL; AB065851; BAC06069.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW73806.1; -; Genomic_DNA.
DR EMBL; BC136947; AAI36948.1; -; mRNA.
DR EMBL; BC136948; AAI36949.1; -; mRNA.
DR EMBL; AF399637; AAK95122.1; -; Genomic_DNA.
DR EMBL; BK004507; DAA04905.1; -; Genomic_DNA.
DR CCDS; CCDS31551.1; -.
DR RefSeq; NP_001004733.1; NM_001004733.2.
DR AlphaFoldDB; Q96R08; -.
DR SMR; Q96R08; -.
DR IntAct; Q96R08; 1.
DR STRING; 9606.ENSP00000306657; -.
DR GlyGen; Q96R08; 2 sites.
DR iPTMnet; Q96R08; -.
DR PhosphoSitePlus; Q96R08; -.
DR BioMuta; OR5B12; -.
DR DMDM; 20532192; -.
DR PaxDb; Q96R08; -.
DR PRIDE; Q96R08; -.
DR ProteomicsDB; 77923; -.
DR Antibodypedia; 58770; 173 antibodies from 21 providers.
DR DNASU; 390191; -.
DR Ensembl; ENST00000302572.2; ENSP00000306657.2; ENSG00000172362.4.
DR Ensembl; ENST00000641921.2; ENSP00000493263.1; ENSG00000172362.4.
DR GeneID; 390191; -.
DR KEGG; hsa:390191; -.
DR MANE-Select; ENST00000641921.2; ENSP00000493263.1; NM_001004733.3; NP_001004733.1.
DR UCSC; uc010rkh.2; human.
DR CTD; 390191; -.
DR DisGeNET; 390191; -.
DR GeneCards; OR5B12; -.
DR HGNC; HGNC:15432; OR5B12.
DR HPA; ENSG00000172362; Not detected.
DR neXtProt; NX_Q96R08; -.
DR PharmGKB; PA32481; -.
DR VEuPathDB; HostDB:ENSG00000172362; -.
DR eggNOG; ENOG502SHXT; Eukaryota.
DR GeneTree; ENSGT01040000240414; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q96R08; -.
DR OMA; MGCYVCG; -.
DR OrthoDB; 1009242at2759; -.
DR PhylomeDB; Q96R08; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q96R08; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390191; 8 hits in 664 CRISPR screens.
DR GeneWiki; OR5B12; -.
DR GenomeRNAi; 390191; -.
DR Pharos; Q96R08; Tdark.
DR PRO; PR:Q96R08; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q96R08; protein.
DR Bgee; ENSG00000172362; Expressed in lymph node and 5 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 5B12"
FT /id="PRO_0000150587"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 261
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 141
FT /note="C -> R (in dbSNP:rs4938895)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_053191"
FT VARIANT 141
FT /note="C -> Y (in dbSNP:rs11229457)"
FT /id="VAR_053192"
SQ SEQUENCE 314 AA; 35182 MW; 93BB84F1CACA68F1 CRC64;
MENNTEVTEF ILVGLTDDPE LQIPLFIVFL FIYLITLVGN LGMIELILLD SCLHTPMYFF
LSNLSLVDFG YSSAVTPKVM VGFLTGDKFI LYNACATQFF FFVAFITAES FLLASMAYDR
YAALCKPLHY TTTMTTNVCA CLAIGSYICG FLNASIHTGN TFRLSFCRSN VVEHFFCDAP
PLLTLSCSDN YISEMVIFFV VGFNDLFSIL VILISYLFIF ITIMKMRSPE GRQKAFSTCA
SHLTAVSIFY GTGIFMYLRP NSSHFMGTDK MASVFYAIVI PMLNPLVYSL RNKEVKSAFK
KTVGKAKASI GFIF
