OR5BH_HUMAN
ID OR5BH_HUMAN Reviewed; 314 AA.
AC Q8NGF7; Q6IEX1;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Olfactory receptor 5B17;
DE AltName: Full=Olfactory receptor 5B20;
DE AltName: Full=Olfactory receptor OR11-237;
GN Name=OR5B17; Synonyms=OR5B20P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5B17";
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DR EMBL; AB065849; BAC06067.1; -; Genomic_DNA.
DR EMBL; BK004491; DAA04889.1; -; Genomic_DNA.
DR CCDS; CCDS31548.1; -.
DR RefSeq; NP_001005489.1; NM_001005489.1.
DR AlphaFoldDB; Q8NGF7; -.
DR SMR; Q8NGF7; -.
DR STRING; 9606.ENSP00000349945; -.
DR GlyGen; Q8NGF7; 1 site.
DR PhosphoSitePlus; Q8NGF7; -.
DR BioMuta; OR5B17; -.
DR DMDM; 38372681; -.
DR PaxDb; Q8NGF7; -.
DR PeptideAtlas; Q8NGF7; -.
DR PRIDE; Q8NGF7; -.
DR Antibodypedia; 70678; 22 antibodies from 12 providers.
DR DNASU; 219965; -.
DR Ensembl; ENST00000357377.3; ENSP00000349945.3; ENSG00000197786.3.
DR GeneID; 219965; -.
DR KEGG; hsa:219965; -.
DR MANE-Select; ENST00000357377.3; ENSP00000349945.3; NM_001005489.2; NP_001005489.1.
DR UCSC; uc010rke.3; human.
DR CTD; 219965; -.
DR DisGeNET; 219965; -.
DR GeneCards; OR5B17; -.
DR HGNC; HGNC:15267; OR5B17.
DR HPA; ENSG00000197786; Not detected.
DR neXtProt; NX_Q8NGF7; -.
DR OpenTargets; ENSG00000197786; -.
DR PharmGKB; PA32486; -.
DR VEuPathDB; HostDB:ENSG00000197786; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT01040000240414; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGF7; -.
DR OMA; IGCYVIG; -.
DR OrthoDB; 979582at2759; -.
DR PhylomeDB; Q8NGF7; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NGF7; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219965; 9 hits in 672 CRISPR screens.
DR GeneWiki; OR5B17; -.
DR GenomeRNAi; 219965; -.
DR Pharos; Q8NGF7; Tdark.
DR PRO; PR:Q8NGF7; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGF7; protein.
DR ExpressionAtlas; Q8NGF7; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 5B17"
FT /id="PRO_0000150588"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 80
FT /note="L -> I (in dbSNP:rs4939208)"
FT /id="VAR_034219"
FT VARIANT 308
FT /note="Y -> C (in dbSNP:rs4127353)"
FT /id="VAR_053193"
SQ SEQUENCE 314 AA; 35091 MW; 952366E31FFD7C52 CRC64;
MENNTEVSEF ILLGLTNAPE LQVPLFIMFT LIYLITLTGN LGMIILILLD SHLHTPMYFF
LSNLSLAGIG YSSAVTPKVL TGLLIEDKAI SYSACAAQMF FCAVFATVEN YLLSSMAYDR
YAAVCNPLHY TTTMTTRVCA CLAIGCYVIG FLNASIQIGD TFRLSFCMSN VIHHFFCDKP
AVITLTCSEK HISELILVLI SSFNVFFALL VTLISYLFIL ITILKRHTGK GYQKPLSTCG
SHLIAIFLFY ITVIIMYIRP SSSHSMDTDK IASVFYTMII PMLSPIVYTL RNKDVKNAFM
KVVEKAKYSL DSVF
