OR5BL_HUMAN
ID OR5BL_HUMAN Reviewed; 309 AA.
AC A6NL26;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Olfactory receptor 5B21;
GN Name=OR5B21;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5B21";
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DR EMBL; AP003557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS31552.1; -.
DR RefSeq; NP_001005218.1; NM_001005218.1.
DR AlphaFoldDB; A6NL26; -.
DR SMR; A6NL26; -.
DR STRING; 9606.ENSP00000353537; -.
DR GlyGen; A6NL26; 2 sites.
DR iPTMnet; A6NL26; -.
DR PhosphoSitePlus; A6NL26; -.
DR BioMuta; OR5B21; -.
DR MassIVE; A6NL26; -.
DR PaxDb; A6NL26; -.
DR PeptideAtlas; A6NL26; -.
DR PRIDE; A6NL26; -.
DR Antibodypedia; 27658; 7 antibodies from 7 providers.
DR DNASU; 219968; -.
DR Ensembl; ENST00000360374.3; ENSP00000353537.2; ENSG00000198283.3.
DR GeneID; 219968; -.
DR KEGG; hsa:219968; -.
DR MANE-Select; ENST00000360374.3; ENSP00000353537.2; NM_001005218.3; NP_001005218.1.
DR UCSC; uc010rki.3; human.
DR CTD; 219968; -.
DR GeneCards; OR5B21; -.
DR HGNC; HGNC:19616; OR5B21.
DR HPA; ENSG00000198283; Not detected.
DR neXtProt; NX_A6NL26; -.
DR OpenTargets; ENSG00000198283; -.
DR PharmGKB; PA134867164; -.
DR VEuPathDB; HostDB:ENSG00000198283; -.
DR eggNOG; ENOG502SKXC; Eukaryota.
DR GeneTree; ENSGT01040000240414; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; A6NL26; -.
DR OMA; GMMVIIH; -.
DR OrthoDB; 1006246at2759; -.
DR PhylomeDB; A6NL26; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; A6NL26; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; A6NL26; -.
DR BioGRID-ORCS; 219968; 12 hits in 669 CRISPR screens.
DR GenomeRNAi; 219968; -.
DR Pharos; A6NL26; Tdark.
DR PRO; PR:A6NL26; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; A6NL26; protein.
DR Bgee; ENSG00000198283; Expressed in urinary bladder and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 5B21"
FT /id="PRO_0000310474"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..95
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 117..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 260
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..177
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 272
FT /note="S -> Y (in dbSNP:rs58454093)"
FT /id="VAR_062041"
SQ SEQUENCE 309 AA; 34174 MW; 5AAA162D09AC8BA1 CRC64;
MENSTEVTEF ILLGLTDDPN LQIPLLLAFL FIYLITLLGN GGMMVIIHSD SHLHTPMYFF
LSNLSLVDLG YSSAVAPKTV AALRSGDKAI SYDGCAAQFF FFVGFATVEC YLLASMAYDR
HAAVCRPLHY TTTMTAGVCA LLATGSYVSG FLNASIHAAG TFRLSFCGSN EINHFFCDIP
PLLALSCSDT RISKLVVFVA GFNVFFTLLV ILISYFFICI TIQRMHSAEG QKKVFSTCAS
HLTALSIFYG TIIFMYLQPN SSQSVDTDKI ASVFYTVVIP MLNPLIYSLR NKEVKSALWK
ILNKLYPQY
