OR5C1_HUMAN
ID OR5C1_HUMAN Reviewed; 320 AA.
AC Q8NGR4; B2RN54; B9EGT0; Q96RC4;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 5C1;
DE AltName: Full=Olfactory receptor 5C2;
DE AltName: Full=Olfactory receptor 9-F;
DE Short=OR9-F;
GN Name=OR5C1; Synonyms=OR5C2P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 72-288.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5C1";
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DR EMBL; AB065725; BAC05946.1; -; Genomic_DNA.
DR EMBL; BC136700; AAI36701.1; -; mRNA.
DR EMBL; BC136701; AAI36702.1; -; mRNA.
DR EMBL; AF399514; AAK94999.1; -; Genomic_DNA.
DR CCDS; CCDS35131.1; -.
DR RefSeq; NP_001001923.1; NM_001001923.1.
DR AlphaFoldDB; Q8NGR4; -.
DR SMR; Q8NGR4; -.
DR BioGRID; 134202; 7.
DR STRING; 9606.ENSP00000362784; -.
DR GlyGen; Q8NGR4; 1 site.
DR iPTMnet; Q8NGR4; -.
DR PhosphoSitePlus; Q8NGR4; -.
DR BioMuta; OR5C1; -.
DR DMDM; 38372754; -.
DR MassIVE; Q8NGR4; -.
DR PaxDb; Q8NGR4; -.
DR PRIDE; Q8NGR4; -.
DR Antibodypedia; 72100; 13 antibodies from 8 providers.
DR DNASU; 392391; -.
DR Ensembl; ENST00000373680.3; ENSP00000362784.2; ENSG00000148215.4.
DR GeneID; 392391; -.
DR KEGG; hsa:392391; -.
DR MANE-Select; ENST00000373680.3; ENSP00000362784.2; NM_001001923.1; NP_001001923.1.
DR UCSC; uc011lzd.2; human.
DR CTD; 392391; -.
DR GeneCards; OR5C1; -.
DR HGNC; HGNC:8331; OR5C1.
DR HPA; ENSG00000148215; Not detected.
DR neXtProt; NX_Q8NGR4; -.
DR PharmGKB; PA32511; -.
DR VEuPathDB; HostDB:ENSG00000148215; -.
DR eggNOG; ENOG502RF3K; Eukaryota.
DR GeneTree; ENSGT01050000244954; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGR4; -.
DR OMA; FVHTTLT; -.
DR OrthoDB; 1130066at2759; -.
DR PhylomeDB; Q8NGR4; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NGR4; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 392391; 14 hits in 674 CRISPR screens.
DR GeneWiki; OR5C1; -.
DR GenomeRNAi; 392391; -.
DR Pharos; Q8NGR4; Tdark.
DR PRO; PR:Q8NGR4; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8NGR4; protein.
DR Bgee; ENSG00000148215; Expressed in sural nerve.
DR ExpressionAtlas; Q8NGR4; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..320
FT /note="Olfactory receptor 5C1"
FT /id="PRO_0000150590"
FT TOPO_DOM 1..29
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..200
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222..241
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..320
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 101..193
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 320 AA; 34991 MW; BFEFBCE40A988BD5 CRC64;
MNSENLTRAA VAPAEFVLLG ITNRWDLRVA LFLTCLPVYL VSLLGNMGMA LLIRMDARLH
TPMYFFLANL SLLDACYSSA IGPKMLVDLL LPRATIPYTA CALQMFVFAG LADTECCLLA
AMAYDRYVAI RNPLLYTTAM SQRLCLALLG ASGLGGAVSA FVHTTLTFRL SFCRSRKINS
FFCDIPPLLA ISCSDTSLNE LLLFAICGFI QTATVLAITV SYGFIAGAVI HMRSVEGSRR
AASTGGSHLT AVAMMYGTLI FMYLRPSSSY ALDTDKMASV FYTLVIPSLN PLIYSLRNKE
VKEALRQTWS RFHCPGQGSQ
