OR5DD_HUMAN
ID OR5DD_HUMAN Reviewed; 314 AA.
AC Q8NGL4; Q6IF68; Q6IFC9;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Olfactory receptor 5D13;
DE AltName: Full=Olfactory receptor OR11-142;
DE AltName: Full=Olfactory receptor OR11-148;
GN Name=OR5D13;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05998.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5D13";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065778; BAC05998.1; ALT_INIT; Genomic_DNA.
DR EMBL; BK004333; DAA04731.1; -; Genomic_DNA.
DR EMBL; BK004394; DAA04792.1; -; Genomic_DNA.
DR RefSeq; NP_001001967.1; NM_001001967.1.
DR AlphaFoldDB; Q8NGL4; -.
DR SMR; Q8NGL4; -.
DR STRING; 9606.ENSP00000354800; -.
DR GlyGen; Q8NGL4; 1 site.
DR iPTMnet; Q8NGL4; -.
DR PhosphoSitePlus; Q8NGL4; -.
DR BioMuta; OR5D13; -.
DR DMDM; 38372723; -.
DR MassIVE; Q8NGL4; -.
DR PaxDb; Q8NGL4; -.
DR PeptideAtlas; Q8NGL4; -.
DR PRIDE; Q8NGL4; -.
DR Antibodypedia; 78666; 109 antibodies from 21 providers.
DR DNASU; 390142; -.
DR Ensembl; ENST00000623930.1; ENSP00000485428.1; ENSG00000279761.2.
DR GeneID; 390142; -.
DR KEGG; hsa:390142; -.
DR MANE-Select; ENST00000623930.1; ENSP00000485428.1; NM_001001967.1; NP_001001967.1.
DR UCSC; uc010ril.2; human.
DR CTD; 390142; -.
DR GeneCards; OR5D13; -.
DR HGNC; HGNC:15280; OR5D13.
DR HPA; ENSG00000279761; Not detected.
DR neXtProt; NX_Q8NGL4; -.
DR PharmGKB; PA32572; -.
DR VEuPathDB; HostDB:ENSG00000279761; -.
DR eggNOG; ENOG502TF14; Eukaryota.
DR GeneTree; ENSGT01050000244804; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NGL4; -.
DR OMA; SGCIMQF; -.
DR OrthoDB; 940316at2759; -.
DR PhylomeDB; Q8NGL4; -.
DR TreeFam; TF352746; -.
DR PathwayCommons; Q8NGL4; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390142; 9 hits in 625 CRISPR screens.
DR GeneWiki; OR5D13; -.
DR GenomeRNAi; 390142; -.
DR Pharos; Q8NGL4; Tdark.
DR PRO; PR:Q8NGL4; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGL4; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 5D13"
FT /id="PRO_0000150591"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 62
FT /note="C -> Y (in dbSNP:rs297118)"
FT /id="VAR_024099"
FT VARIANT 124
FT /note="R -> H (in dbSNP:rs11230983)"
FT /id="VAR_024100"
FT VARIANT 236
FT /note="R -> L (in dbSNP:rs7124871)"
FT /id="VAR_034220"
SQ SEQUENCE 314 AA; 35447 MW; CA6C3082912FD150 CRC64;
MMASERNQSS TPTFILLGFS EYPEIQVPLF LVFLFVYTVT VVGNLGMIII IRLNSKLHTI
MCFFLSHLSL TDFCFSTVVT PKLLENLVVE YRTISFSGCI MQFCFACIFG VTETFMLAAM
AYDRFVAVCK PLLYTTIMSQ KLCALLVAGS YTWGIVCSLI LTYFLLDLSF CESTFINNFI
CDHSVIVSAS YSDPYISQRL CFIIAIFNEV SSLIIILTSY MLIFTTIMKM RSASGRQKTF
STCASHLTAI TIFHGTILFL YCVPNPKTSS LIVTVASVFY TVAIPMLNPL IYSLRNKDIN
NMFEKLVVTK LIYH
