OR5DE_HUMAN
ID OR5DE_HUMAN Reviewed; 314 AA.
AC Q8NGL3; Q6IF69; Q6IFD4; Q96RB5;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Olfactory receptor 5D14;
DE AltName: Full=Olfactory receptor OR11-141;
DE AltName: Full=Olfactory receptor OR11-150;
GN Name=OR5D14;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-285, AND VARIANT ALA-249.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5D14";
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DR EMBL; AB065779; BAC05999.1; -; Genomic_DNA.
DR EMBL; AF399523; AAK95008.1; -; Genomic_DNA.
DR EMBL; BK004328; DAA04726.1; -; Genomic_DNA.
DR EMBL; BK004393; DAA04791.1; -; Genomic_DNA.
DR CCDS; CCDS31508.1; -.
DR RefSeq; NP_001004735.1; NM_001004735.1.
DR AlphaFoldDB; Q8NGL3; -.
DR SMR; Q8NGL3; -.
DR STRING; 9606.ENSP00000334456; -.
DR GlyGen; Q8NGL3; 2 sites.
DR iPTMnet; Q8NGL3; -.
DR PhosphoSitePlus; Q8NGL3; -.
DR BioMuta; OR5D14; -.
DR DMDM; 38372722; -.
DR MassIVE; Q8NGL3; -.
DR PaxDb; Q8NGL3; -.
DR PeptideAtlas; Q8NGL3; -.
DR PRIDE; Q8NGL3; -.
DR Antibodypedia; 72059; 19 antibodies from 11 providers.
DR DNASU; 219436; -.
DR Ensembl; ENST00000335605.1; ENSP00000334456.1; ENSG00000186113.1.
DR GeneID; 219436; -.
DR KEGG; hsa:219436; -.
DR MANE-Select; ENST00000335605.1; ENSP00000334456.1; NM_001004735.1; NP_001004735.1.
DR UCSC; uc010rim.2; human.
DR CTD; 219436; -.
DR GeneCards; OR5D14; -.
DR HGNC; HGNC:15281; OR5D14.
DR HPA; ENSG00000186113; Not detected.
DR neXtProt; NX_Q8NGL3; -.
DR PharmGKB; PA32517; -.
DR VEuPathDB; HostDB:ENSG00000186113; -.
DR eggNOG; ENOG502T6WP; Eukaryota.
DR GeneTree; ENSGT01050000244804; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NGL3; -.
DR OMA; CMMQYFL; -.
DR OrthoDB; 971844at2759; -.
DR PhylomeDB; Q8NGL3; -.
DR TreeFam; TF352746; -.
DR PathwayCommons; Q8NGL3; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219436; 7 hits in 666 CRISPR screens.
DR GeneWiki; OR5D14; -.
DR GenomeRNAi; 219436; -.
DR Pharos; Q8NGL3; Tdark.
DR PRO; PR:Q8NGL3; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGL3; protein.
DR Bgee; ENSG00000186113; Expressed in ascending aorta.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 5D14"
FT /id="PRO_0000150592"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 249
FT /note="S -> A (in dbSNP:rs297054)"
FT /evidence="ECO:0000269|PubMed:12213199"
FT /id="VAR_034221"
FT VARIANT 290
FT /note="L -> P (in dbSNP:rs297055)"
FT /id="VAR_034222"
SQ SEQUENCE 314 AA; 35823 MW; 60990285FCD1CAD8 CRC64;
MMMVLRNLSM EPTFALLGFT DYPKLQIPLF LVFLLMYVIT VVGNLGMIII IKINPKFHTP
MYFFLSHLSF VDFCYSSIVT PKLLENLVMA DKSIFYFSCM MQYFLSCTAV VTESFLLAVM
AYDRFVAICN PLLYTVAMSQ RLCALLVAGS YLWGMFGPLV LLCYALRLNF SGPNVINHFF
CEYTALISVS GSDILIPHLL LFSFATFNEM CTLLIILTSY VFIFVTVLKI RSVSGRHKAF
STWASHLTSI TIFHGTILFL YCVPNSKNSR QTVKVASVFY TVVNPMLNPL IYSLRNKDVK
DAFWKLIHTQ VPFH
