OR5DG_HUMAN
ID OR5DG_HUMAN Reviewed; 328 AA.
AC Q8NGK9; Q6IF65; Q96RB4;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Olfactory receptor 5D16;
DE AltName: Full=Olfactory receptor OR11-154;
GN Name=OR5D16;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-285.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5D16";
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DR EMBL; AB065783; BAC06003.1; -; Genomic_DNA.
DR EMBL; AF399524; AAK95009.1; -; Genomic_DNA.
DR EMBL; BK004397; DAA04795.1; -; Genomic_DNA.
DR CCDS; CCDS31512.1; -.
DR RefSeq; NP_001005496.1; NM_001005496.1.
DR AlphaFoldDB; Q8NGK9; -.
DR SMR; Q8NGK9; -.
DR STRING; 9606.ENSP00000367649; -.
DR GlyGen; Q8NGK9; 1 site.
DR BioMuta; OR5D16; -.
DR DMDM; 38372718; -.
DR MassIVE; Q8NGK9; -.
DR PaxDb; Q8NGK9; -.
DR PeptideAtlas; Q8NGK9; -.
DR PRIDE; Q8NGK9; -.
DR Antibodypedia; 58946; 45 antibodies from 18 providers.
DR DNASU; 390144; -.
DR Ensembl; ENST00000378396.1; ENSP00000367649.1; ENSG00000205029.1.
DR GeneID; 390144; -.
DR KEGG; hsa:390144; -.
DR MANE-Select; ENST00000378396.1; ENSP00000367649.1; NM_001005496.1; NP_001005496.1.
DR UCSC; uc010rio.2; human.
DR CTD; 390144; -.
DR GeneCards; OR5D16; -.
DR HGNC; HGNC:15283; OR5D16.
DR HPA; ENSG00000205029; Not detected.
DR neXtProt; NX_Q8NGK9; -.
DR PharmGKB; PA32519; -.
DR VEuPathDB; HostDB:ENSG00000205029; -.
DR eggNOG; ENOG502T9ND; Eukaryota.
DR GeneTree; ENSGT01050000244804; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGK9; -.
DR OMA; FNRINHF; -.
DR OrthoDB; 1059975at2759; -.
DR PhylomeDB; Q8NGK9; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NGK9; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390144; 7 hits in 663 CRISPR screens.
DR GeneWiki; OR5D16; -.
DR GenomeRNAi; 390144; -.
DR Pharos; Q8NGK9; Tdark.
DR PRO; PR:Q8NGK9; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGK9; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..328
FT /note="Olfactory receptor 5D16"
FT /id="PRO_0000150593"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..328
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 156
FT /note="A -> T (in dbSNP:rs6591700)"
FT /id="VAR_034223"
SQ SEQUENCE 328 AA; 37278 MW; 9833B589C043992E CRC64;
MFLTERNTTS EATFTLLGFS DYLELQIPLF FVFLAVYGFS VVGNLGMIVI IKINPKLHTP
MYFFLNHLSF VDFCYSSIIA PMMLVNLVVE DRTISFSGCL VQFFFFCTFV VTELILFAVM
AYDHFVAICN PLLYTVAISQ KLCAMLVVVL YAWGVACSLT LACSALKLSF HGFNTINHFF
CELSSLISLS YPDSYLSQLL LFTVATFNEI STLLIILTSY AFIIVTTLKM PSASGHRKVF
STCASHLTAI TIFHGTILFL YCVPNSKNSR HTVKVASVFY TVVIPLLNPL IYSLRNKDVK
DAIRKIINTK YFHIKHRHWY PFNFVIEQ
