OR5F1_HUMAN
ID OR5F1_HUMAN Reviewed; 314 AA.
AC O95221; Q495D1; Q6IFB9;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2001, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Olfactory receptor 5F1;
DE AltName: Full=Olfactory receptor 11-10;
DE Short=OR11-10;
DE AltName: Full=Olfactory receptor OR11-167;
GN Name=OR5F1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ASN-294.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-294.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=9787077; DOI=10.1006/geno.1998.5422;
RA Buettner J.A., Glusman G., Ben-Arie N., Ramos P., Lancet D., Evans G.A.;
RT "Organization and evolution of olfactory receptor genes on human chromosome
RT 11.";
RL Genomics 53:56-68(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5F1";
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DR EMBL; CH471076; EAW73694.1; -; Genomic_DNA.
DR EMBL; BC101239; AAI01240.1; -; mRNA.
DR EMBL; BC101241; AAI01242.1; -; mRNA.
DR EMBL; AF065863; AAC70017.1; -; Genomic_DNA.
DR EMBL; AF399527; AAK95012.1; -; Genomic_DNA.
DR EMBL; BK004343; DAA04741.1; -; Genomic_DNA.
DR CCDS; CCDS31515.1; -.
DR RefSeq; NP_003688.1; NM_003697.1.
DR AlphaFoldDB; O95221; -.
DR SMR; O95221; -.
DR BioGRID; 130779; 12.
DR IntAct; O95221; 9.
DR STRING; 9606.ENSP00000278409; -.
DR GlyGen; O95221; 1 site.
DR iPTMnet; O95221; -.
DR PhosphoSitePlus; O95221; -.
DR BioMuta; OR5F1; -.
DR MassIVE; O95221; -.
DR PaxDb; O95221; -.
DR PeptideAtlas; O95221; -.
DR PRIDE; O95221; -.
DR ProteomicsDB; 50725; -.
DR Antibodypedia; 58954; 102 antibodies from 21 providers.
DR DNASU; 338674; -.
DR Ensembl; ENST00000278409.1; ENSP00000278409.1; ENSG00000149133.1.
DR GeneID; 338674; -.
DR KEGG; hsa:338674; -.
DR MANE-Select; ENST00000278409.1; ENSP00000278409.1; NM_003697.1; NP_003688.1.
DR UCSC; uc010riv.2; human.
DR CTD; 338674; -.
DR GeneCards; OR5F1; -.
DR HGNC; HGNC:8343; OR5F1.
DR HPA; ENSG00000149133; Not detected.
DR MIM; 608492; gene.
DR neXtProt; NX_O95221; -.
DR PharmGKB; PA32526; -.
DR VEuPathDB; HostDB:ENSG00000149133; -.
DR eggNOG; ENOG502SJ0I; Eukaryota.
DR GeneTree; ENSGT01050000244804; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; O95221; -.
DR OMA; FYATCIY; -.
DR OrthoDB; 1123691at2759; -.
DR PhylomeDB; O95221; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; O95221; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; O95221; -.
DR BioGRID-ORCS; 338674; 11 hits in 635 CRISPR screens.
DR GeneWiki; OR5F1; -.
DR GenomeRNAi; 338674; -.
DR Pharos; O95221; Tdark.
DR PRO; PR:O95221; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; O95221; protein.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 5F1"
FT /id="PRO_0000150595"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 192
FT /note="T -> A (in dbSNP:rs35607186)"
FT /id="VAR_062043"
FT VARIANT 278
FT /note="Y -> H (in dbSNP:rs11825964)"
FT /id="VAR_053194"
FT VARIANT 294
FT /note="S -> N (in dbSNP:rs2449134)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_034225"
SQ SEQUENCE 314 AA; 35132 MW; C14A9A35CD76E3A3 CRC64;
MTRKNYTSLT EFVLLGLADT LELQIILFLF FLVIYTLTVL GNLGMILLIR IDSQLHTPMY
FFLANLSFVD VCNSTTITPK MLADLLSEKK TISFAGCFLQ MYFFISLATT ECILFGLMAY
DRYAAICRPL LYSLIMSRTV YLKMAAGAFA AGLLNFMVNT SHVSSLSFCD SNVIHHFFCD
SPPLFKLSCS DTILKESISS ILAGVNIVGT LLVILSSYSY VLFSIFSMHS GEGRHRAFST
CASHLTAIIL FYATCIYTYL RPSSSYSLNQ DKVASVFYTV VIPMLNPLIY SLRSKEVKKA
LANVISRKRT SSFL
